Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 2/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.49 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22398101 | 0.88 | TSHR (0.50) | PTPN2PTPN1PTPN6PTPN11TSHR | |
| SCHEMBL15807681 | 0.84 | PTPN2 (0.46) | PTPN2PTPN1PTPN6PTPN11CASP3 | |
| SCHEMBL13520584 | 0.83 | FFAR1 (0.52) | PTPN2PTPN1PTPN6PTPN11CASP3 | |
| SCHEMBL18452361 | 0.82 | KDM4E (0.53) | CHRNB4CHRNA3ALDH1A1MAPTMEN1 | |
| SCHEMBL1309403 | 0.82 | PTPN2 (0.47) | PTPN2PTPN1PTPN6PTPN11CASP3 | |
| SCHEMBL1311725 | 0.82 | PTPN2 (0.45) | PTPN2PTPN1PTPN6PTPN11TSHR | |
| SCHEMBL6690856 | 0.82 | ALDH1A1 (0.50) | PTPN2PTPN1PTPN6PTPN11TSHR | |
| SCHEMBL6318644 | 0.81 | TSHR (0.48) | TSHRCASP3SENP8SENP7SENP6 | |
| Bicarbonate SCHEMBL25419740 | 0.81 | PTPN2 (0.47) | PTPN2PTPN1PTPN6PTPN11TSHR | |
| SCHEMBL6690094 | 0.81 | ALDH1A1 (0.49) | PTPN2PTPN1PTPN6PTPN11TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170327472-A1 | CHLORO-PYRAZINE CARBOXAMIDE DERIVATIVES WITH EPITHELIAL SODIUM CHANNEL BLOCKING ACTIVITY | PARION SCIENCES, INC. (US) | 2017-11-16 | — | — | US | disclosed |
| US-20170327472-A1 | CHLORO-PYRAZINE CARBOXAMIDE DERIVATIVES WITH EPITHELIAL SODIUM CHANNEL BLOCKING ACTIVITY | PARION SCIENCES, INC. (US) | 2017-11-16 | — | — | US | disclosed |
| EP-3150585-A1 | CHLORO-PYRAZINE CARBOXAMIDE DERIVATIVES WITH EPITHELIAL SODIUM CHANNEL BLOCKING ACTIVITY | Parion Sciences, Inc. (US) | 2017-04-05 | — | — | EP | disclosed |
| US-9593084-B2 | Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity | PARION SCIENCES, INC. (US) | 2017-03-14 | — | — | US | disclosed |
| US-9593084-B2 | Chloro-pyrazine carboxamide derivatives with epithelial sodium channel blocking activity | PARION SCIENCES, INC. (US) | 2017-03-14 | — | — | US | disclosed |
| US-20140171447-A1 | CHLORO-PYRAZINE CARBOXAMIDE DERIVATIVES WITH EPITHELIAL SODIUM CHANNEL BLOCKING ACTIVITY | PARION SCIENCES, INC. (US) | 2014-06-19 | — | — | US | disclosed |
| US-20140171447-A1 | CHLORO-PYRAZINE CARBOXAMIDE DERIVATIVES WITH EPITHELIAL SODIUM CHANNEL BLOCKING ACTIVITY | PARION SCIENCES, INC. (US) | 2014-06-19 | — | — | US | disclosed |
| US-7642391-B1 | Palladium-catalyzed coupling of aryl halides with alkynes | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2010-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140171447-A1 | CHLORO-PYRAZINE CARBOXAMIDE DERIVATIVES WITH EPITHELIAL SODIUM CHANNEL BLOCKING ACTIVITY | SCNN1B, SCNN1A, SCNN1G | PTPN2 2346/4885PTPN1 2811/4885PTPN6 2948/4885 |
| US-20170327472-A1 | CHLORO-PYRAZINE CARBOXAMIDE DERIVATIVES WITH EPITHELIAL SODIUM CHANNEL BLOCKING ACTIVITY | SCNN1B, SCNN1A, SCNN1G | PTPN2 2346/4885PTPN1 2811/4885PTPN6 2948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.