SCHEMBL6690856

SCHEMBL6690856

O=[N+]([O-])c1cccc(C#CCCCCO)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.50
MAPT P10636 3/20 0.50
HSP90AA1 P07900 2/20 0.50
HTT P42858 2/20 0.50
NPSR1 Q6W5P4 2/20 0.50
S1PR2 O95136 1/20 0.50
OPRK1 P41145 1/20 0.50
FFAR1 O14842 1/20 0.49
HTR2C P28335 1/20 0.46
HTR2B P41595 1/20 0.46
PTPN2 P17706 1/20 0.46
PTPN1 P18031 1/20 0.46
PTPN6 P29350 1/20 0.46
PTPN11 Q06124 1/20 0.46
CHRNB4 P30926 2/20 0.46
CHRNA3 P32297 2/20 0.46
TSHR P16473 3/20 0.44
LMNA P02545 2/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6690094 0.99 ALDH1A1 (0.49) ALDH1A1MAPTHSP90AA1HTTNPSR1
SCHEMBL1312435 0.96 ALDH1A1 (0.51) ALDH1A1MAPTHSP90AA1HTTNPSR1
SCHEMBL6697515 0.90 ALDH1A1 (0.54) ALDH1A1MAPTHSP90AA1HTTNPSR1
SCHEMBL6682165 0.84 NPSR1 (0.46) ALDH1A1MAPTHSP90AA1HTTNPSR1
SCHEMBL6682672 0.84 ALDH1A1 (0.48) ALDH1A1MAPTHSP90AA1HTTNPSR1
SCHEMBL6692873 0.83 ALDH1A1 (0.56) ALDH1A1MAPTHSP90AA1HTTNPSR1
SCHEMBL13520587 0.82 PTPN2 (0.49) ALDH1A1MAPTHSP90AA1NPSR1OPRK1
SCHEMBL12379592 0.81 PTPN2 (0.46) ALDH1A1MAPTHSP90AA1HTTNPSR1
SCHEMBL22301347 0.81 ALDH1A1 (0.50) ALDH1A1MAPTHSP90AA1HTTNPSR1
SCHEMBL6702166 0.81 MAPT (0.45) ALDH1A1MAPTHSP90AA1HTTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004106292-A1 HALOETHYL UREA COMPOUNDS AND THEIR USE TO ATTENUATE, INHIBIT OR PREVENT NON-CANCEROUS PATHOGENIC CELLULAR PROLIFERATION AND DISEASES ASSOCIATED THEREWITH IMOTEP INC. (CA) 2004-12-09 WO disclosed
WO-2004106291-A1 HALOETHYL UREA COMPOUNDS AND THE USE THEREOF TO ATTENUATE, INHIBIT OR PREVENT CANCER CELL MIGRATION IMOTEP INC. (CA) 2004-12-09 WO disclosed