Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL10418863 | 0.93 | HSD11B1 (0.42) | EPHA2KDREPHB4RAB9ASMN1; SMN2 | |
| SCHEMBL8874613 | 0.91 | GPR119 (0.37) | EPHA2KDREPHB4RAB9ANPC1 | |
| SCHEMBL13722060 | 0.88 | EPHA2 (0.41) | EPHA2KDREPHB4KCNH2RAB9A | |
| Oxalic Acid SCHEMBL9369618 | 0.86 | CHRM2 (0.42) | RAB9ASMN1; SMN2NPC1TSHRHSD11B1 | |
| SCHEMBL13522003 | 0.82 | RAB9A (0.35) | RAB9ASMN1; SMN2MAPK1GAANPC1 | |
| SCHEMBL12049807 | 0.81 | GPR119 (0.40) | EPHA2KDREPHB4RAB9ASMN1; SMN2 | |
| SCHEMBL6468604 | 0.81 | RAB9A (0.41) | RAB9ASMN1; SMN2MAPK1GAANPC1 | |
| SCHEMBL17909944 | 0.80 | CHRM2 (0.48) | RAB9ASMN1; SMN2NPC1TSHRHSD11B1 | |
| SCHEMBL660531 | 0.80 | CHRM2 (0.48) | RAB9ASMN1; SMN2NPC1TSHRHSD11B1 | |
| SCHEMBL12073942 | 0.79 | RAB9A (0.47) | RAB9ASMN1; SMN2MAPK1GAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004284-A1 | Novel Heterocyclic Compounds as Positive Allosteric Modulators of Metabotropic Glutamate Receptors | ADDEX PHARMA SA (CH) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004284-A1 | Novel Heterocyclic Compounds as Positive Allosteric Modulators of Metabotropic Glutamate Receptors | GRM5, GRM1, GRIK5 | EPHA2 2938/4885KDR 4214/4885EPHB4 2664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.