Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.82 |
| ▸ | KIT | P10721 | 8/20 | 0.82 |
| ▸ | FLT3 | P36888 | 8/20 | 0.82 |
| ▸ | CSF1R | P07333 | 7/20 | 0.82 |
| ▸ | FLT1 | P17948 | 7/20 | 0.82 |
| ▸ | FLT4 | P35916 | 7/20 | 0.82 |
| ▸ | LYN | P07948 | 6/20 | 0.82 |
| ▸ | BLK | P51451 | 6/20 | 0.82 |
| ▸ | LCK | P06239 | 6/20 | 0.82 |
| ▸ | SRC | P12931 | 5/20 | 0.82 |
| ▸ | FYN | P06241 | 4/20 | 0.82 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.64 |
| ▸ | ABL1 | P00519 | 3/20 | 0.64 |
| ▸ | AURKA | O14965 | 3/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.64 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1702794 | 0.90 | KDR (1.00) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL13209956 | 0.89 | KDR (0.80) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL13523220 | 0.84 | KDR (0.81) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL13873001 | 0.83 | KDR (0.69) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL13523215 | 0.80 | KDR (0.83) | KDRKITFLT3CSF1RFLT1 | |
| Linifanib SCHEMBL93804 | 0.78 | KDR (1.00) | KDRKITFLT3CSF1RFLT1 | |
| Linifanib SCHEMBL29375368 | 0.78 | KDR (1.00) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL6073436 | 0.78 | KDR (0.79) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL12426039 | 0.77 | KDR (0.77) | KDRKITFLT3CSF1RFLT1 | |
| SCHEMBL1702799 | 0.77 | KDR (1.00) | KDRKITFLT3CSF1RFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004306-A1 | PIGF-1 Assay and kits and components thereof | ABBOTT LABORATORIES (US) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004306-A1 | PIGF-1 Assay and kits and components thereof | PGF, FLT1, HDGF | KDR 9/4885KIT 140/4885FLT3 773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.