Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.54 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91582 | 0.90 | MKNK1 (0.51) | EIF2AK2KCNH3SMN1; SMN2HSD17B10MKNK1 | |
| SCHEMBL13403107 | 0.81 | HRH4 (0.56) | KCNH3HTTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL11988630 | 0.80 | EIF2AK2 (0.48) | EIF2AK2KCNH3HTTSMN1; SMN2HSD17B10 | |
| SCHEMBL84013 | 0.80 | EIF2AK2 (0.48) | EIF2AK2KCNH3HTTSMN1; SMN2HSD17B10 | |
| SCHEMBL13484616 | 0.80 | NUDT1 (0.49) | EIF2AK2KCNH3HTTNPSR1HRH4 | |
| SCHEMBL28248600 | 0.80 | DNM2 (0.57) | KCNH3HTTNPSR1HRH4MAPT | |
| SCHEMBL12844540 | 0.79 | EIF2AK2 (0.47) | EIF2AK2KCNH3HTTSMN1; SMN2HSD17B10 | |
| SCHEMBL4716836 | 0.79 | HRH3 (0.45) | NPSR1HRH4KDRMAPTCYP2C9 | |
| SCHEMBL12775924 | 0.78 | EIF2AK2 (0.46) | EIF2AK2KCNH3HTTSMN1; SMN2HSD17B10 | |
| SCHEMBL91452 | 0.78 | NPSR1 (0.46) | SMN1; SMN2LMNANPSR1HRH4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865732-B2 | Heterocyclic compounds and uses thereof | NOVARTIS AG (CH) | 2014-10-21 | — | — | US | disclosed |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | NOVARTIS AG (CH) | 2013-08-15 | — | — | US | disclosed |
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | NOVARTIS AG (CH) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | BRAF, ARAF, KRAS | EIF2AK2 1680/4885KCNH3 4595/4885HTT 2408/4885 |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | BRAF, RAF1, HRAS | EIF2AK2 1666/4885KCNH3 3814/4885HTT 3739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.