Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | DNM2 | P50570 | 2/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13034199 | 0.88 | CXCR4 (0.54) | MAPTCYP2C9CXCR4NPSR1SYK | |
| SCHEMBL28248600 | 0.85 | DNM2 (0.57) | MAPTDNM2HRH4NPSR1 | |
| SCHEMBL13403107 | 0.83 | HRH4 (0.56) | MAPTCYP2C9DNM2HRH4NPSR1 | |
| SCHEMBL13484616 | 0.81 | NUDT1 (0.49) | MAPTCYP2C9DNM2HRH4NPSR1 | |
| SCHEMBL91452 | 0.79 | NPSR1 (0.46) | MAPTCYP2C9DNM2HRH4NPSR1 | |
| SCHEMBL13524816 | 0.79 | EIF2AK2 (0.54) | MAPTCYP2C9DNM2HRH4NPSR1 | |
| SCHEMBL12280402 | 0.78 | DYRK1B (0.46) | HRH3DYRK1BPIM1PIM2DNM2 | |
| SCHEMBL10625591 | 0.77 | KMT2A (0.55) | DNM2 | |
| SCHEMBL10225045 | 0.77 | MAPK1 (0.59) | MAPTCYP2C9NPSR1 | |
| SCHEMBL28661902 | 0.77 | DNM2 (0.64) | HRH3DYRK1BDNM2STK17AHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216230-B1 | FUSED CYCLOHEPTANE AND FUSED AZACYCLOHEPTANE COMPOUNDS AND THEIR USE AS INTEGRIN RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2008-04-23 | — | — | EP | disclosed |
| US-6514964-B1 | Treating diseases, conditions or disorders mediated by integrin receptors, such as vitronectin and fibronectin receptors | AMGEN INC. | 2003-02-04 | — | — | US | disclosed |