Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 7/20 | 0.43 |
| ▸ | CHRM4 known ✓ | P08173 | 7/20 | 0.43 |
| ▸ | CHRM5 known ✓ | P08912 | 7/20 | 0.43 |
| ▸ | CHRM1 known ✓ | P11229 | 7/20 | 0.43 |
| ▸ | CHRM3 known ✓ | P20309 | 7/20 | 0.43 |
| ▸ | HRH2 known ✓ | P25021 | 2/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | XBP1 | P17861 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.55 |
| ▸ | BLM | P54132 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL135287 | 1.00 | PRMT1 (0.60) | PRMT1NPC1RAB9AMEN1LMNA | |
| SCHEMBL24767157 | 0.91 | PRMT1 (0.56) | PRMT1NPC1RAB9AMEN1LMNA | |
| SCHEMBL18685192 | 0.89 | PRMT1 (0.60) | PRMT1NPC1RAB9AMEN1LMNA | |
| SCHEMBL12334550 | 0.89 | PRMT1 (0.60) | PRMT1NPC1RAB9AMEN1LMNA | |
| SCHEMBL18070299 | 0.88 | PRMT1 (0.61) | PRMT1NPC1RAB9AMEN1LMNA | |
| SCHEMBL30591065 | 0.88 | PRMT1 (0.57) | PRMT1NPC1RAB9AMEN1LMNA | |
| SCHEMBL178255 | 0.88 | PRMT1 (0.57) | PRMT1NPC1RAB9AMEN1LMNA | |
| SCHEMBL23155071 | 0.88 | PRMT1 (0.55) | PRMT1NPC1RAB9AMEN1LMNA | |
| Hydrochloric Acid SCHEMBL29456067 | 0.87 | PRMT1 (0.56) | PRMT1NPC1RAB9AMEN1LMNA | |
| Hydrochloric Acid SCHEMBL29465555 | 0.87 | PRMT1 (0.56) | PRMT1NPC1RAB9AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8530634-B2 | Method of oligonucleotide labeling using cycloaddition reaction | CHEMGENES CORPORATION (US) | 2013-09-10 | — | — | US | disclosed |
| US-20120058476-A1 | Method Of Oligonucleotide Labeling Using Cycloaddition Reaction | CHEMGENES CORPORATION | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058476-A1 | Method Of Oligonucleotide Labeling Using Cycloaddition Reaction | CBR3, CYB5R3, DUT | CHRM2 4220/4885CHRM4 2607/4885CHRM5 2466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.