Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 5/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12265177 | 0.90 | ADORA2B (0.58) | ADORA2BADORA1ADORA2AALDH1A1MAPK1 | |
| SCHEMBL1779353 | 0.73 | ADORA2B (0.80) | ADORA2BADORA1ADORA2A | |
| SCHEMBL1782085 | 0.67 | ADORA2B (0.67) | ADORA2BADORA1ADORA2AALDH1A1 | |
| SCHEMBL1780170 | 0.66 | ADORA2B (1.00) | ADORA2BADORA1ADORA2A | |
| SCHEMBL1222451 | 0.65 | ADORA2B (1.00) | ADORA2BADORA1ADORA2A | |
| SCHEMBL5823542 | 0.64 | ADORA2B (0.56) | ADORA2BADORA1ADORA2AMAPK1 | |
| SCHEMBL1780518 | 0.63 | ADORA2B (0.79) | ADORA2BADORA1ADORA2A | |
| SCHEMBL3395773 | 0.60 | ADORA2B (0.78) | ADORA2BADORA1ADORA2AKDM4ELMNA | |
| SCHEMBL1781522 | 0.59 | ADORA2B (0.78) | ADORA2BADORA1ADORA2A | |
| SCHEMBL1782219 | 0.59 | ADORA2B (0.78) | ADORA2BADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010009194-A1 | METHODS OF TREATING ATHEROSCLEROSIS | KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) | 2010-01-21 | — | — | WO | disclosed |