Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.76 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.65 |
| ▸ | AR | P10275 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | ODC1 | P11926 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.50 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Hydroxyisolonchocarpin SCHEMBL13535456 | 0.85 | XDH (0.81) | XDHPTPN1ARHPGDALDH1A1 | |
| SCHEMBL19960677 | 0.84 | XDH (0.80) | XDHPTPN1HPGDALDH1A1CYP3A4 | |
| SCHEMBL30383083 | 0.79 | PTPN1 (1.00) | XDHPTPN1HPGDALDH1A1CYP3A4 | |
| SCHEMBL7654646 | 0.78 | AR (0.68) | ARHPGDALDH1A1CYP3A4MAPT | |
| SCHEMBL7654653 | 0.78 | AR (0.68) | ARHPGDALDH1A1CYP3A4MAPT | |
| SCHEMBL29644903 | 0.78 | KDM4E (0.63) | PTPN1HPGDALDH1A1CYP3A4MAPT | |
| SCHEMBL7664544 | 0.74 | MAPT (0.86) | ARHPGDALDH1A1CYP3A4MAPT | |
| SCHEMBL7664540 | 0.74 | MAPT (0.86) | ARHPGDALDH1A1CYP3A4MAPT | |
| SCHEMBL25241260 | 0.74 | MAPT (0.66) | PTPN1ARHPGDALDH1A1CYP3A4 | |
| SCHEMBL13905820 | 0.74 | MAPT (0.66) | PTPN1ARHPGDALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010006189-A2 | SMALL-MOLECULE INHIBITORS OF HIF AND ANGIOGENESIS | EMORY UNIVERSITY (US) | 2010-01-14 | — | — | WO | disclosed |