Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8346866 | 0.85 | MEN1 (0.39) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL13536805 | 0.80 | TRPA1 (0.45) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL13741101 | 0.79 | MEN1 (0.46) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL3390179 | 0.75 | MAPT (0.42) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL5207242 | 0.75 | NPC1 (0.43) | MAPTGAAMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL1492472 | 0.73 | NPC1 (0.42) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL13827578 | 0.67 | NPC1 (0.46) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL2411151 | 0.67 | TAAR1 (0.58) | MAPTMEN1KMT2AALDH1A1TP53 | |
| SCHEMBL8524757 | 0.67 | MEN1 (0.44) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL1491116 | 0.66 | HAO1 (0.46) | MAPTHAO1DHODHRAPGEF4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2140864-A2 | Use of GAL3 receptor antagonists for the treatment of depression and / or anxiety and compounds useful in such methods | H.Lundbeck A/S (DK) | 2010-01-06 | — | — | EP | disclosed |