Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | UBE2I | P63279 | 1/20 | 0.38 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.38 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13741101 | 0.80 | MEN1 (0.46) | MAPTMEN1GAAKMT2AALDH1A1 | |
| SCHEMBL5207242 | 0.76 | NPC1 (0.43) | MAPTMEN1GAAKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL1492472 | 0.75 | NPC1 (0.42) | MAPTMEN1GAAKMT2AALDH1A1 | |
| SCHEMBL13536733 | 0.75 | MAPT (0.45) | MAPTMEN1GAAKMT2AALDH1A1 | |
| SCHEMBL13827578 | 0.68 | NPC1 (0.46) | MAPTMEN1GAAKMT2AALDH1A1 | |
| SCHEMBL1491116 | 0.67 | HAO1 (0.46) | MAPTHAO1DHODHRAPGEF4HPGD | |
| SCHEMBL7679004 | 0.67 | RAPGEF4 (0.44) | MAPTMEN1GAAKMT2AALDH1A1 | |
| SCHEMBL13827691 | 0.66 | MAPT (0.65) | MAPTMEN1GAAKMT2AALDH1A1 | |
| SCHEMBL916183 | 0.65 | HPGD (0.56) | MAPTMEN1GAAKMT2AALDH1A1 | |
| SCHEMBL9516537 | 0.65 | HPGD (0.78) | MAPTMEN1GAAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |