Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12153091 | 0.87 | MEN1 (0.57) | GAAPOLBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7148287 | 0.84 | SMN1; SMN2 (0.59) | POLBSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL8237577 | 0.79 | ALDH1A1 (0.56) | GAAPOLBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8403545 | 0.78 | POLB (0.61) | GAAPOLBKMT2AALDH1A1TSHR | |
| SCHEMBL19825999 | 0.78 | SMN1; SMN2 (0.46) | POLBSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL7517494 | 0.78 | KMT2A (0.54) | GAAPOLBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL21386360 | 0.78 | SRC (0.52) | GAAPOLBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL10131962 | 0.78 | POLB (0.48) | GAAPOLBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14495580 | 0.77 | POLB (0.52) | GAAPOLBKMT2AALDH1A1TSHR | |
| SCHEMBL13514007 | 0.77 | PTPN1 (0.56) | POLBSMN1; SMN2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652014-B2 | effective in radiosensitizing (hypoxic) tumor cells and effective in preventing tumor cells from recovering from potentially lethal and sublethal damage of DNA after radiation therapy; minimal side effects | JANSSEN PHARMACEUTICA (BE) | 2010-01-26 | — | — | US | disclosed |
| US-7652014-B2 | effective in radiosensitizing (hypoxic) tumor cells and effective in preventing tumor cells from recovering from potentially lethal and sublethal damage of DNA after radiation therapy; minimal side effects | JANSSEN PHARMACEUTICA (BE) | 2010-01-26 | — | — | US | disclosed |
| US-20090042881-A1 | SUBSTITUTED 6-CYCLOHEXYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-02-12 | — | — | US | disclosed |
| US-20090042881-A1 | SUBSTITUTED 6-CYCLOHEXYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042881-A1 | SUBSTITUTED 6-CYCLOHEXYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS | PARP1, PARP2, PARP3 | GAA 1075/4885POLB 45/4885SMN1; SMN2 3061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.