Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 9/20 | 0.63 |
| ▸ | PIM2 | Q9P1W9 | 9/20 | 0.63 |
| ▸ | PIM3 | Q86V86 | 7/20 | 0.63 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.47 |
| ▸ | TTR | P02766 | 2/20 | 0.42 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12282336 | 0.91 | PIM1 (0.65) | PIM1PIM2PIM3NR1H4TTR | |
| Hydrochloric Acid SCHEMBL2424222 | 0.90 | PIM1 (0.64) | PIM1PIM2PIM3NR1H4TTR | |
| Hydrochloric Acid SCHEMBL2424216 | 0.90 | PIM1 (0.64) | PIM1PIM2PIM3NR1H4TTR | |
| Hydrochloric Acid SCHEMBL2424218 | 0.90 | PIM1 (0.64) | PIM1PIM2PIM3NR1H4TTR | |
| SCHEMBL13537622 | 0.84 | NR1H4 (0.47) | PIM1PIM2PIM3NR1H4TTR | |
| SCHEMBL13537960 | 0.83 | PIM2 (0.66) | PIM1PIM2PIM3NR1H4 | |
| SCHEMBL13537962 | 0.83 | GPR119 (0.49) | PIM1PIM2PIM3NR1H4PTPN1 | |
| SCHEMBL1580364 | 0.78 | PIM2 (1.00) | PIM1PIM2PIM3TTRMEN1 | |
| SCHEMBL1580360 | 0.78 | PIM2 (1.00) | PIM1PIM2PIM3TTRMEN1 | |
| SCHEMBL2425657 | 0.77 | GPR119 (0.49) | PIM1PIM2PIM3NR1H4TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001169-A2 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2010-01-07 | — | — | WO | disclosed |