Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CTSA | P10619 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12376697 | 0.80 | KDM4E (0.49) | KDM4EPOLBLMNA | |
| SCHEMBL949992 | 0.77 | CASP1 (0.43) | — | |
| SCHEMBL8764660 | 0.77 | CASP1 (0.43) | — | |
| SCHEMBL13753486 | 0.77 | ATM (0.49) | KDM4EPOLBLMNA | |
| SCHEMBL15771458 | 0.76 | ALDH1A1 (0.54) | KDM4ELMNA | |
| SCHEMBL15771457 | 0.76 | ALDH1A1 (0.54) | KDM4ELMNA | |
| SCHEMBL7108670 | 0.76 | GRN (0.54) | KDM4EPOLB | |
| SCHEMBL27607727 | 0.75 | KDM4E (0.46) | TSHRKDM4EPOLBLMNA | |
| SCHEMBL1170963 | 0.75 | KDM4E (0.46) | TSHRKDM4EPOLBLMNA | |
| SCHEMBL3242636 | 0.75 | KDM4E (0.55) | TSHRKDM4EPOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |