Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 3/20 | 0.54 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1170963 | 0.85 | KDM4E (0.46) | KDM4EPOLB | |
| SCHEMBL27607727 | 0.85 | KDM4E (0.46) | KDM4EPOLB | |
| SCHEMBL10779891 | 0.80 | KISS1R (0.46) | KDM4E | |
| SCHEMBL1603738 | 0.79 | TSHR (0.51) | CA2CA1KDM4E | |
| SCHEMBL9417260 | 0.79 | L3MBTL1 (0.56) | CA2CA1MME | |
| SCHEMBL7211001 | 0.79 | PSMB5 (0.48) | — | |
| Leucine SCHEMBL7211002 | 0.79 | LTA4H (0.49) | — | |
| SCHEMBL12376697 | 0.77 | KDM4E (0.49) | KDM4EPOLB | |
| SCHEMBL2158900 | 0.76 | CTSL (0.67) | GRNSORT1CA2CA1ALDH1A1 | |
| SCHEMBL4465251 | 0.76 | CTSL (0.67) | GRNSORT1CA2CA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019434-B1 | INHIBITORS OF METALLOPROTEINASES, THEIR THERAPEUTIC USE, AND PROCESS FOR THE PRODUCTION OF THE STARTING COMPOUND IN THEIR SYNTHESIS | POLIFARMA SPA (IT) | 2003-10-01 | — | — | EP | disclosed |
| US-6339160-B1 | FOR THERAPY OF TUMORAL GROWTH AND METASTATIZATION, ATEROSCLEROSIS, MULTIPLE SCLEROSIS, ALZHEIMER'S DISEASE, OSTEOPOROSIS, HYPERTENSION, RHEUMATOID ARTHRITIS AND OTHER INFLAMMATORY DISEASES | POLIFARMA S.P.A. (IT) | 2002-01-15 | — | — | US | disclosed |
| EP-1019434-A2 | INHIBITORS OF METALLOPROTEINASES, THEIR THERAPEUTIC USE, AND PROCESS FOR THE PRODUCTION OF THE STARTING COMPOUND IN THEIR SYNTHESIS | POLIFARMA S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999003878-A2 | INHIBITORS OF METALLOPROTEINASES, THEIR THERAPEUTIC USE, AND PROCESS FOR THE PRODUCTION OF THE STARTING COMPOUND IN THEIR SYNTHESIS | POLIFARMA S.P.A. (IT) | 1999-01-28 | — | — | WO | disclosed |