Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13544707 | 0.84 | HSD11B1 (0.50) | HSD11B1ALDH1A1SMN1; SMN2HPGDNPSR1 | |
| SCHEMBL10132087 | 0.81 | HSD11B1 (0.69) | HSD11B1ALDH1A1SMN1; SMN2HPGDNPSR1 | |
| SCHEMBL23518502 | 0.81 | HSD11B1 (0.54) | HSD11B1ALDH1A1SMN1; SMN2HPGDNPSR1 | |
| SCHEMBL23518575 | 0.81 | HSD11B1 (0.54) | HSD11B1ALDH1A1SMN1; SMN2HPGDNPSR1 | |
| SCHEMBL1515374 | 0.81 | HSD11B1 (0.54) | HSD11B1ALDH1A1SMN1; SMN2HPGDNPSR1 | |
| SCHEMBL13544500 | 0.81 | ALDH1A1 (0.46) | HSD11B1ALDH1A1SMN1; SMN2HPGDNPSR1 | |
| SCHEMBL3620374 | 0.78 | HSD11B1 (0.61) | HSD11B1ALDH1A1SMN1; SMN2HPGDNPSR1 | |
| SCHEMBL12478049 | 0.78 | HSD11B1 (0.51) | HSD11B1ALDH1A1SMN1; SMN2HPGDNPSR1 | |
| SCHEMBL21884192 | 0.76 | HSD11B1 (0.58) | HSD11B1ALDH1A1SMN1; SMN2HPGDNPSR1 | |
| SCHEMBL7373129 | 0.76 | SMN1; SMN2 (0.44) | HSD11B1ALDH1A1SMN1; SMN2HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |