Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13544500 | 0.85 | ALDH1A1 (0.46) | SMN1; SMN2HPGDALDH1A1GNAI3GNAO1 | |
| SCHEMBL22870418 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2HPGDALDH1A1GNAI3GNAO1 | |
| SCHEMBL13544707 | 0.81 | HSD11B1 (0.50) | SMN1; SMN2HPGDALDH1A1HSD11B1MEN1 | |
| SCHEMBL21131668 | 0.76 | RAB9A (0.46) | SMN1; SMN2HPGDALDH1A1GNAI3GNAO1 | |
| SCHEMBL15684107 | 0.76 | SMN1; SMN2 (0.57) | SMN1; SMN2HPGDALDH1A1GNAI3GNAO1 | |
| SCHEMBL10132085 | 0.75 | SMN1; SMN2 (0.65) | SMN1; SMN2HPGDALDH1A1GNAI3GNAO1 | |
| SCHEMBL9125344 | 0.74 | HPGD (0.62) | SMN1; SMN2HPGDALDH1A1HDAC3HDAC1 | |
| SCHEMBL13544828 | 0.74 | SMN1; SMN2 (0.54) | SMN1; SMN2HPGDALDH1A1GNAI3GNAO1 | |
| SCHEMBL22859123 | 0.73 | EPHX2 (0.42) | SMN1; SMN2HPGDALDH1A1GNAI3GNAO1 | |
| SCHEMBL20581686 | 0.71 | SMN1; SMN2 (0.56) | SMN1; SMN2HPGDALDH1A1GNAI3GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |