Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | PABPC1 | P11940 | 3/20 | 0.51 |
| ▸ | EIF4H | Q15056 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 4/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.43 |
| ▸ | DHPS | P49366 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13996074 | 0.85 | RAB9A (0.54) | KMT2AMEN1PABPC1EIF4HRAB9A | |
| SCHEMBL3596391 | 0.83 | KMT2A (0.41) | KMT2AMEN1PABPC1EIF4HLMNA | |
| SCHEMBL3585389 | 0.81 | RAF1 (0.40) | KMT2AMEN1PABPC1EIF4HRAB9A | |
| SCHEMBL3585387 | 0.81 | RAF1 (0.40) | KMT2AMEN1PABPC1EIF4HRAB9A | |
| SCHEMBL13544491 | 0.79 | TRPV1 (0.68) | KMT2ASMN1; SMN2TRPV1ALDH1A1MAPT | |
| SCHEMBL16455987 | 0.76 | KDR (0.64) | KMT2AMEN1LMNARAB9ANPC1 | |
| SCHEMBL13544672 | 0.72 | TRPV1 (0.58) | TRPV1 | |
| SCHEMBL13544272 | 0.72 | RAF1 (0.40) | KMT2AMEN1PABPC1EIF4HLMNA | |
| SCHEMBL13544259 | 0.70 | RAF1 (0.40) | KMT2AMEN1PABPC1EIF4HLMNA | |
| SCHEMBL13544516 | 0.69 | BTK (0.50) | SMN1; SMN2TRPV1TP53THRBPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004222-A1 | Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same | RENOVIS, INC. (US) | 2010-01-07 | — | — | US | disclosed |
| US-7576099-B2 | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same | RENOVIS, INC. (US) | 2009-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004222-A1 | Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same | TRPV1, TRPA1, TRPV2 | KMT2A 4280/4885MEN1 4500/4885PABPC1 3457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.