Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.44 |
| ▸ | FEN1 | P39748 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2040317 | 0.84 | MCL1 (0.64) | MCL1SMN1; SMN2L3MBTL1KDM1AKMT2A | |
| SCHEMBL13543265 | 0.80 | MCL1 (0.53) | MCL1MAPTSMN1; SMN2KDM1AKMT2A | |
| SCHEMBL4667179 | 0.79 | MCL1 (0.61) | MCL1MAPTSMN1; SMN2L3MBTL1KDM1A | |
| SCHEMBL31645593 | 0.78 | KDM1A (0.60) | MCL1SMN1; SMN2L3MBTL1KDM1AKMT2A | |
| SCHEMBL4533547 | 0.78 | KDM1A (0.60) | MCL1SMN1; SMN2L3MBTL1KDM1AKMT2A | |
| SCHEMBL7183442 | 0.77 | LMNA (0.64) | MCL1MAPTSMN1; SMN2L3MBTL1KDM1A | |
| SCHEMBL4535022 | 0.76 | KDM1A (0.53) | MCL1L3MBTL1KDM1AKMT2ACDK1 | |
| SCHEMBL7183438 | 0.75 | KDM1A (0.58) | MCL1SMN1; SMN2L3MBTL1KDM1AKMT2A | |
| SCHEMBL1474479 | 0.75 | HPGD (0.63) | SMN1; SMN2KMT2APTGS2LMNAHTT | |
| SCHEMBL23864381 | 0.74 | KDM1A (0.51) | MCL1L3MBTL1KDM1ACDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |