Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 5/20 | 0.39 |
| ▸ | ACACA | Q13085 | 5/20 | 0.39 |
| ▸ | CNR1 | P21554 | 3/20 | 0.39 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | IL2 | P60568 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13548038 | 1.00 | THRB (0.42) | THRBLMNAACACBACACACNR1 | |
| SCHEMBL2353015 | 0.96 | THRB (0.41) | THRBLMNAACACBACACACNR1 | |
| SCHEMBL13548099 | 0.94 | THRB (0.40) | THRBLMNAACACBACACACNR1 | |
| SCHEMBL2349821 | 0.89 | ACACB (0.49) | THRBLMNAACACBACACACNR1 | |
| SCHEMBL13548083 | 0.89 | THRB (0.41) | THRBLMNAACACBACACACNR1 | |
| SCHEMBL13548098 | 0.89 | THRB (0.41) | THRBLMNAACACBACACACNR1 | |
| SCHEMBL13548037 | 0.89 | ACACB (0.38) | THRBLMNAACACBACACACNR1 | |
| SCHEMBL13548029 | 0.89 | ACACB (0.38) | THRBLMNAACACBACACACNR1 | |
| SCHEMBL2356692 | 0.89 | ACACB (0.49) | THRBLMNAACACBACACACNR1 | |
| SCHEMBL13548031 | 0.88 | CNR1 (0.40) | THRBLMNAACACBACACACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100022527-A1 | BIPHENYL SUBSTITUTED SPIROTETRONIC ACIDS AND THEIR USE FOR THE TREATMENT OF RETROVIRAL DISEASES | AICURIS GMBH & CO. KG (DE) | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022527-A1 | BIPHENYL SUBSTITUTED SPIROTETRONIC ACIDS AND THEIR USE FOR THE TREATMENT OF RETROVIRAL DISEASES | DHFR, RORA, CYP2A6 | THRB 245/4885LMNA 1617/4885ACACB 2720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.