Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3522806 | 0.93 | LMNA (0.41) | GSK3BLMNAADORA3CA1CA2 | |
| SCHEMBL13548369 | 0.86 | LMNA (0.55) | GSK3BLMNAADORA3ALDH1A1HTT | |
| SCHEMBL11867921 | 0.81 | ALDH1A1 (0.37) | LMNACA1CA2ALDH1A1ALOX12 | |
| SCHEMBL11478019 | 0.75 | LMNA (0.48) | GSK3BLMNAADORA3ALDH1A1HTT | |
| SCHEMBL3522021 | 0.74 | GSK3B (0.48) | GSK3BLMNAADORA3ALDH1A1ALOX12 | |
| SCHEMBL3523104 | 0.74 | BRD4 (0.52) | LMNAADORA3ALDH1A1KMT2AGAA | |
| SCHEMBL11724082 | 0.74 | LMNA (0.39) | GSK3BLMNAADORA3ALDH1A1MAPT | |
| SCHEMBL11487326 | 0.72 | SMN1; SMN2 (0.40) | LMNAADORA3ALDH1A1KMT2AGAA | |
| SCHEMBL11817708 | 0.71 | LMNA (0.50) | LMNAADORA3ALDH1A1KMT2A | |
| SCHEMBL11017764 | 0.70 | LMNA (0.73) | LMNAADORA3CA1CA2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652006-B2 | For therapy and prophylaxis of neuronal loss associated with stroke, global and focal ischemia, CNS trauma, hypoglycemia and surgery, for ameliorating neurodegenerative diseases | EURO-CELTIQUE S.A. (LU) | 2010-01-26 | — | — | US | disclosed |
| US-7652006-B2 | For therapy and prophylaxis of neuronal loss associated with stroke, global and focal ischemia, CNS trauma, hypoglycemia and surgery, for ameliorating neurodegenerative diseases | EURO-CELTIQUE S.A. (LU) | 2010-01-26 | — | — | US | disclosed |