Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 10/20 | 0.57 |
| ▸ | BACE1 | P56817 | 8/20 | 0.57 |
| ▸ | BCHE | P06276 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CCR3 | P51677 | 1/20 | 0.50 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12844707 | 0.92 | BACE1 (0.59) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL3307906 | 0.86 | ACHE (0.62) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL1448701 | 0.81 | ACHE (0.56) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL2498286 | 0.78 | ACHE (0.73) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL4848458 | 0.78 | MEN1 (0.55) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL360075 | 0.78 | ACHE (0.68) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL2885290 | 0.78 | BACE1 (0.64) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL13761943 | 0.78 | BACE1 (0.64) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL8259147 | 0.78 | BACE1 (0.64) | ACHEBACE1BCHEMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2766858 | 0.77 | ACHE (0.71) | ACHEBACE1BCHEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642278-B2 | Nitrogen compounds such as 3-(5-morpholin-4-yl-1H-benz-imidazol-2-yl)-1H-indazole and/or isomers, used as immunology modulators, antidiabetic agents, antiogenesis inhibitors or for prophylaxis of Alzheimer's disease | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-01-05 | — | — | US | disclosed |