Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18908323 | 1.00 | CYP3A4 (0.49) | CYP3A4ALDH1A1KMT2ACYP2D6HPGD | |
| SCHEMBL13554080 | 1.00 | CYP3A4 (0.49) | CYP3A4ALDH1A1KMT2ACYP2D6HPGD | |
| SCHEMBL17724493 | 0.86 | CYP2D6 (0.46) | CYP3A4ALDH1A1KMT2ACYP2D6SRC | |
| SCHEMBL24327749 | 0.86 | CYP2D6 (0.46) | CYP3A4ALDH1A1KMT2ACYP2D6SRC | |
| SCHEMBL3940548 | 0.86 | CYP2D6 (0.46) | CYP3A4ALDH1A1KMT2ACYP2D6SRC | |
| SCHEMBL4213669 | 0.83 | ALDH1A1 (0.55) | CYP3A4ALDH1A1KMT2ACYP2D6HPGD | |
| SCHEMBL22758082 | 0.82 | ALOX5 (0.46) | CYP3A4ALDH1A1KMT2ACYP2D6SRC | |
| SCHEMBL15472452 | 0.81 | ALDH1A1 (0.46) | CYP3A4ALDH1A1KMT2ACYP2D6HCAR2 | |
| Hydrogen Peroxide SCHEMBL28172808 | 0.81 | ALDH1A1 (0.64) | CYP3A4ALDH1A1KMT2ALMNA | |
| SCHEMBL13709475 | 0.81 | ALDH1A1 (0.46) | CYP3A4ALDH1A1KMT2ACYP2D6HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120270934-A1 | PROSTACYCLIN DERIVATIVES | CONCERT PHARMACEUTICALS, INC. | 2012-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270934-A1 | PROSTACYCLIN DERIVATIVES | PTGIS, PTGIR, PTGER1 | CYP3A4 1496/4885ALDH1A1 1386/4885KMT2A 4701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.