Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 10/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 10/20 | 0.48 |
| ▸ | AURKA | O14965 | 9/20 | 0.48 |
| ▸ | CDK4 | P11802 | 3/20 | 0.41 |
| ▸ | CCND1 | P24385 | 3/20 | 0.41 |
| ▸ | CCND2 | P30279 | 3/20 | 0.41 |
| ▸ | CCND3 | P30281 | 3/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 3/20 | 0.40 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1353795 | 0.87 | DCLK1 (0.52) | CDK1CCNB1AURKACDK4CCND1 | |
| SCHEMBL3573049 | 0.85 | CDK1 (0.46) | CDK1CCNB1AURKACDK4CCND1 | |
| SCHEMBL3581811 | 0.82 | CDK1 (0.44) | CDK1CCNB1AURKACDK4CCND1 | |
| SCHEMBL1353745 | 0.81 | AURKA (0.53) | AURKA | |
| SCHEMBL1356005 | 0.80 | CDK1 (0.43) | CDK1CCNB1AURKACYP3A4CYP2C9 | |
| SCHEMBL3862278 | 0.78 | AURKA (0.48) | CDK1CCNB1AURKACDK4CCND1 | |
| SCHEMBL3591861 | 0.78 | AURKA (0.54) | CDK1CCNB1AURKACDK4CCND1 | |
| SCHEMBL3587869 | 0.78 | CDK1 (0.47) | CDK1CCNB1AURKACDK4CCND1 | |
| SCHEMBL3586266 | 0.77 | AURKA (0.42) | CDK1CCNB1AURKACDK4CCND1 | |
| SCHEMBL1356000 | 0.77 | AURKA (0.44) | CDK1CCNB1AURKACDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110281821-A9 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2011-11-17 | — | — | US | claimed |
| US-20100249067-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2010-09-30 | — | — | US | claimed |
| US-20110281821-A9 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2011-11-17 | — | — | US | disclosed |
| US-20100249067-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249067-A1 | Modulators of Mitotic Kinases | BUB1, BUB1B, CDK1 | CDK1 3/4885CCNB1 12/4885AURKA 9/4885 |
| US-20110281821-A9 | Modulators of Mitotic Kinases | BUB1, BUB1B, CDK1 | CDK1 3/4885CCNB1 12/4885AURKA 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.