Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 14/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 14/20 | 0.44 |
| ▸ | AURKA | O14965 | 12/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | WEE1 | P30291 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 4/20 | 0.36 |
| ▸ | CCND1 | P24385 | 4/20 | 0.36 |
| ▸ | CCND2 | P30279 | 4/20 | 0.36 |
| ▸ | CCND3 | P30281 | 4/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CCNH | P51946 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3573049 | 0.93 | CDK1 (0.46) | CDK1CCNB1AURKACYP3A4CYP2C9 | |
| SCHEMBL1355974 | 0.88 | DCLK1 (0.46) | CDK1CCNB1AURKACYP2C9CDK4 | |
| SCHEMBL3585804 | 0.84 | CDK1 (0.46) | CDK1CCNB1AURKACYP3A4CYP2C9 | |
| SCHEMBL3586411 | 0.83 | SRC (0.40) | CDK1CCNB1AURKAWEE1CDK4 | |
| SCHEMBL1355558 | 0.82 | CDK1 (0.48) | CDK1CCNB1AURKACYP3A4CYP2C9 | |
| SCHEMBL3579319 | 0.81 | GSK3B (0.50) | AURKA | |
| SCHEMBL1356005 | 0.81 | CDK1 (0.43) | CDK1CCNB1AURKACYP3A4CYP2C9 | |
| SCHEMBL1356073 | 0.77 | STAT6 (0.50) | CDK1CCNB1AURKACDK4CCND1 | |
| SCHEMBL1355910 | 0.77 | FGFR4 (0.50) | CDK1CCNB1AURKACYP3A4CYP2C9 | |
| SCHEMBL3591261 | 0.77 | GSK3A (0.39) | CDK1CCNB1AURKAWEE1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | CDK1, BUB1, BUB1B | CDK1 1/4885CCNB1 17/4885AURKA 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.