Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.56 |
| ▸ | TOP1 | P11387 | 4/20 | 0.53 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | F3 | P13726 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | USP7 | Q93009 | 1/20 | 0.48 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.48 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.46 |
| ▸ | APLNR | P35414 | 1/20 | 0.46 |
| ▸ | CCR6 | P51684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13559858 | 0.95 | NFKB1 (0.52) | PTPN1TOP1IKBKBNFKB1NFKB2 | |
| SCHEMBL18411779 | 0.95 | NFKB1 (0.52) | PTPN1TOP1IKBKBNFKB1NFKB2 | |
| SCHEMBL13559859 | 0.94 | PTPN1 (0.56) | PTPN1TOP1IKBKBNFKB1NFKB2 | |
| SCHEMBL13559906 | 0.93 | PTPN1 (0.56) | PTPN1TOP1IKBKBNFKB1NFKB2 | |
| SCHEMBL13559878 | 0.91 | PTPN1 (0.55) | PTPN1TOP1POLBF3USP2 | |
| SCHEMBL13559866 | 0.91 | NFKB1 (0.52) | PTPN1TOP1IKBKBNFKB1NFKB2 | |
| SCHEMBL26677442 | 0.91 | TOP1 (0.49) | PTPN1TOP1IKBKBNFKB1NFKB2 | |
| SCHEMBL22144725 | 0.91 | PTPN1 (0.47) | PTPN1TOP1IKBKBNFKB1NFKB2 | |
| SCHEMBL18411765 | 0.90 | PTPN1 (0.46) | PTPN1TOP1IKBKBNFKB1NFKB2 | |
| SCHEMBL18407022 | 0.90 | NFKB1 (0.51) | PTPN1TOP1IKBKBNFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230340012-A1 | NATURAL AND SYNTHETIC COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES | PACIFIC ARROW LTD (CN) | 2023-10-26 | — | — | US | disclosed |
| US-20230159436-A1 | APPLICATIONS OF AMIDE ANALOGS OF TRITERPENES IN CURES OF CANCER AND OTHER DISEASES | PACIFIC ARROW LTD (CN) | 2023-05-25 | — | — | US | disclosed |
| US-20200199172-A1 | NATURAL AND SYNTHETIC COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES | PACIFIC ARROW LTD (CN) | 2020-06-25 | — | — | US | disclosed |
| US-20170267714-A1 | NATURAL AND SYNTHETIC COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES | PACIFIC ARROW LTD (CN) | 2017-09-21 | — | — | US | disclosed |
| US-20170267714-A1 | NATURAL AND SYNTHETIC COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES | PACIFIC ARROW LTD (CN) | 2017-09-21 | — | — | US | disclosed |
| US-20170022246-A1 | NATURAL AND SYNTHETIC COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES | PACIFIC ARROW LTD (CN) | 2017-01-26 | — | — | US | disclosed |
| US-20170022246-A1 | NATURAL AND SYNTHETIC COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES | PACIFIC ARROW LTD (CN) | 2017-01-26 | — | — | US | disclosed |
| US-9434677-B2 | Natural and synthetic compounds for treating cancer and other diseases | PACIFIC ARROW LIMITED (HK) | 2016-09-06 | — | — | US | disclosed |
| US-8785405-B2 | Compounds for treating cancer and other diseases | PACIFIC ARROW LIMITED (CN) | 2014-07-22 | — | — | US | disclosed |
| US-20140199378-A1 | NEW NATURAL AND SYNTHETIC COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES | PACIFIC ARROW LIMITED (CN) | 2014-07-17 | — | — | US | disclosed |
| US-20140024113-A1 | COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES | PACIFIC ARROW LIMITED (CN) | 2014-01-23 | — | — | US | disclosed |
| US-20120277308-A1 | COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES | PACIFIC ARROW LIMITED (CN) | 2012-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140024113-A1 | COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES | TEK, VCAM1, EPCAM | PTPN1 1667/4885TOP1 3713/4885IKBKB 845/4885 |
| US-20170022246-A1 | NATURAL AND SYNTHETIC COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES | VCAM1, EPCAM, ICAM1 | PTPN1 2251/4885TOP1 4774/4885IKBKB 112/4885 |
| US-20200199172-A1 | NATURAL AND SYNTHETIC COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES | VCAM1, EPCAM, ICAM1 | PTPN1 2170/4885TOP1 4774/4885IKBKB 113/4885 |
| US-20230340012-A1 | NATURAL AND SYNTHETIC COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES | TEK, VCAM1, MCL1 | PTPN1 1266/4885TOP1 3389/4885IKBKB 1332/4885 |
| US-20120277308-A1 | COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES | TEK, VCAM1, EPCAM | PTPN1 1667/4885TOP1 3713/4885IKBKB 845/4885 |
| US-20230159436-A1 | APPLICATIONS OF AMIDE ANALOGS OF TRITERPENES IN CURES OF CANCER AND OTHER DISEASES | UACA, BRDT, FLT3 | PTPN1 3361/4885TOP1 1831/4885IKBKB 578/4885 |
| US-20140199378-A1 | NEW NATURAL AND SYNTHETIC COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES | VCAM1, EPCAM, TEK | PTPN1 2253/4885TOP1 4760/4885IKBKB 143/4885 |
| US-20170267714-A1 | NATURAL AND SYNTHETIC COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES | VCAM1, EPCAM, ICAM1 | PTPN1 2251/4885TOP1 4774/4885IKBKB 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.