Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13560440 | 0.91 | CCR2 (0.39) | CCR2LMNAPOLBSMN1; SMN2ELANE | |
| SCHEMBL13560567 | 0.81 | CCR2 (0.35) | CCR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL3638008 | 0.79 | NOD2 (0.53) | CCR2SMN1; SMN2ELANEF2PLAU | |
| SCHEMBL2001099 | 0.74 | CYP19A1 (0.46) | CCR2CYP19A1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL29780834 | 0.74 | MAPT (0.44) | CCR2CYP19A1LMNASMN1; SMN2ELANE | |
| SCHEMBL28808278 | 0.74 | MAPT (0.44) | CCR2CYP19A1LMNASMN1; SMN2ELANE | |
| SCHEMBL13560510 | 0.74 | SRD5A2 (0.35) | SMN1; SMN2MEN1KMT2AALDH1A1GAA | |
| SCHEMBL6750905 | 0.73 | CYP19A1 (0.49) | CCR2CYP19A1LMNAPOLBMEN1 | |
| SCHEMBL26597102 | 0.72 | ELANE (0.45) | CCR2CYP19A1POLBELANEF2 | |
| SCHEMBL28808282 | 0.72 | CCR2 (0.47) | CCR2CYP19A1LMNAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304419-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2012-11-06 | — | — | US | disclosed |