Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 14/20 | 0.53 |
| ▸ | BRD4 | O60885 | 4/20 | 0.53 |
| ▸ | BRD9 | Q9H8M2 | 4/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCND2 | P30279 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | BRD1 | O95696 | 7/20 | 0.36 |
| ▸ | BRPF3 | Q9ULD4 | 4/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | BCL6 | P41182 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35211518 | 1.00 | BRPF1 (0.53) | BRPF1BRD4BRD9CA12CA9 | |
| SCHEMBL2614351 | 0.76 | BRPF1 (0.55) | BRPF1BRD4BRD9CA12CA9 | |
| SCHEMBL35211872 | 0.75 | BTK (0.50) | CDK4CCND1CCND2CCND3KDM4E | |
| SCHEMBL13560811 | 0.71 | BRPF1 (0.58) | BRPF1BRD4BRD9CA12CA9 | |
| SCHEMBL248619 | 0.70 | BRPF1 (1.00) | BRPF1BRD4BRD9CA12CA9 | |
| Hydrochloric Acid SCHEMBL1236989 | 0.68 | BRPF1 (0.96) | BRPF1BRD4BRD9CA12CA9 | |
| SCHEMBL35212128 | 0.67 | CDK4 (0.35) | CDK4CCND1CCND2CCND3 | |
| SCHEMBL14438036 | 0.67 | PIK3CB (0.52) | BRPF1BRD4BRD9PIK3CBKDM4E | |
| SCHEMBL1119899 | 0.67 | BRPF1 (0.59) | BRPF1BRD4BRD9CA12CA9 | |
| Hydrochloric Acid SCHEMBL7218030 | 0.67 | BRPF1 (0.92) | BRPF1BRD4BRD9CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420649-B2 | Pyrido[3,2-d]pyridazine-2(1H)-one compounds as p38 modulators and methods of use thereof | AMGEN INC. (US) | 2013-04-16 | — | — | US | disclosed |
| US-20110281864-A1 | Pyrido[3,2-d]Pyridazine-2(1H)-One Compounds as p38 Modulators and Methods of Use Thereof | AMGEN INC. (US) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281864-A1 | Pyrido[3,2-d]Pyridazine-2(1H)-One Compounds as p38 Modulators and Methods of Use Thereof | MAPK1, MAPK3, MAP4K2 | BRPF1 1088/4885BRD4 982/4885BRD9 2669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.