Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13626053 | 0.87 | HTR6 (0.46) | HTR6CA1CA2PTGS1PTGS2 | |
| SCHEMBL13563338 | 0.74 | HTR6 (0.53) | HTR6CA1CA2PTGS1PTGS2 | |
| SCHEMBL14624291 | 0.74 | HTR6 (0.59) | HTR6CA1CA2PTGS1PTGS2 | |
| SCHEMBL14217957 | 0.74 | HTR6 (0.52) | HTR6CA1CA2 | |
| SCHEMBL13563274 | 0.72 | HTR6 (0.57) | HTR6CA1CA2PTGS1PTGS2 | |
| SCHEMBL14218039 | 0.72 | HTR6 (0.43) | HTR6CA1CA2PTGS1PTGS2 | |
| SCHEMBL13478801 | 0.71 | HTR6 (0.55) | HTR6CA1CA2PTGS1PTGS2 | |
| SCHEMBL13563336 | 0.71 | HTR6 (0.46) | HTR6CA1CA2PTGS1PTGS2 | |
| SCHEMBL13563257 | 0.71 | HTR6 (0.46) | HTR6CA1CA2PARP1PTGS1 | |
| SCHEMBL15899412 | 0.70 | HTR6 (0.57) | HTR6CA1CA2PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297100-B1 | TETRAHYDROCYCLOPENTA[B]INDOLE ANDROGEN RECEPTOR MODULATORS | LILLY CO ELI (US) | 2012-10-31 | — | — | EP | disclosed |