Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10114194 | 0.84 | KMT2A (0.47) | ALDH1A1KDM4EDRD2HCRTR1ADRA1A | |
| SCHEMBL13564861 | 0.79 | POLB (0.44) | ALDH1A1 | |
| SCHEMBL17090086 | 0.79 | POLB (0.44) | ALDH1A1 | |
| SCHEMBL11935188 | 0.79 | ALDH1A1 (0.48) | ALDH1A1KDM4EHTR1AHCRTR1ADRA1D | |
| SCHEMBL13564847 | 0.76 | CNR1 (0.36) | ALDH1A1KDM4EDRD2SLC2A1CNR1 | |
| SCHEMBL13565581 | 0.76 | CA12 (0.43) | ALDH1A1DRD2L3MBTL1 | |
| SCHEMBL13565419 | 0.75 | MEN1 (0.46) | ALDH1A1DRD2TSHR | |
| SCHEMBL13564862 | 0.75 | SMN1; SMN2 (0.39) | ALDH1A1HTR6DRD2L3MBTL1 | |
| SCHEMBL13565544 | 0.75 | TSHR (0.42) | ALDH1A1KDM4EHSD17B10CNR2TSHR | |
| SCHEMBL17089948 | 0.75 | TSHR (0.42) | ALDH1A1KDM4EHSD17B10CNR2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |