Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.44 |
| ▸ | GAA | P10253 | 8/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 7/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | GFER | P55789 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13105770 | 1.00 | MAPT (0.44) | MAPTGAAL3MBTL1RAB9ANPC1 | |
| SCHEMBL17090480 | 1.00 | MAPT (0.44) | MAPTGAAL3MBTL1RAB9ANPC1 | |
| SCHEMBL17090550 | 1.00 | MAPT (0.44) | MAPTGAAL3MBTL1RAB9ANPC1 | |
| SCHEMBL11935854 | 0.88 | GHSR (0.40) | MAPTKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL11940095 | 0.88 | GHSR (0.40) | MAPTKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL13565349 | 0.87 | MAPT (0.40) | MAPTGAAL3MBTL1RAB9ANPC1 | |
| SCHEMBL13565668 | 0.87 | L3MBTL1 (0.38) | MAPTGAAL3MBTL1RAB9ANPC1 | |
| SCHEMBL17090283 | 0.87 | MAPT (0.40) | MAPTGAAL3MBTL1RAB9ANPC1 | |
| SCHEMBL13462876 | 0.87 | GAA (0.41) | MAPTGAAL3MBTL1RAB9ANPC1 | |
| SCHEMBL17090223 | 0.87 | GAA (0.41) | MAPTGAAL3MBTL1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |