Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565279 | 0.90 | ALDH1A1 (0.48) | MAPTGAASMN1; SMN2KDM4EALOX15 | |
| SCHEMBL13566057 | 0.88 | ALDH1A1 (0.39) | ALDH1A1TSHRPOLBNPC1RAB9A | |
| SCHEMBL11936078 | 0.88 | MAPT (0.42) | MAPTGAASMN1; SMN2KDM4EALOX15 | |
| SCHEMBL13565269 | 0.88 | ALDH1A1 (0.43) | MAPTKDM4EMAPK1ALDH1A1POLB | |
| SCHEMBL17090252 | 0.86 | CA1 (0.41) | ALDH1A1POLBHPGDCA12CA1 | |
| SCHEMBL11935923 | 0.84 | ALDH1A1 (0.48) | MAPTGAASMN1; SMN2KDM4EALOX15 | |
| SCHEMBL13565961 | 0.83 | DDB1 (0.37) | MAPTGAASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL17090234 | 0.82 | APP (0.44) | SMN1; SMN2KDM4EALDH1A1POLBHPGD | |
| SCHEMBL13565898 | 0.81 | KDM4E (0.48) | MAPTGAASMN1; SMN2KDM4EALOX15 | |
| SCHEMBL10116267 | 0.81 | LMNA (0.50) | MAPTGAASMN1; SMN2KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |