Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 7/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.34 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565915 | 0.84 | GLO1 (0.37) | GLO1CKS1BSKP2APPLMNA | |
| SCHEMBL10115463 | 0.84 | ALDH1A1 (0.41) | GRIA1LMNAALDH1A1 | |
| SCHEMBL11935694 | 0.80 | ADORA2A (0.39) | GLO1 | |
| SCHEMBL11941034 | 0.77 | GRIA1 (0.46) | GRIA1NPY5RGRIA4 | |
| SCHEMBL13566068 | 0.76 | TP53 (0.39) | GLO1CKS1BSKP2APPLMNA | |
| SCHEMBL13565278 | 0.74 | GRIA1 (0.43) | GRIA1NPY5RGRIA4 | |
| SCHEMBL13565137 | 0.74 | GRIA2 (0.33) | NPY5RGLO1CKS1BSKP2GRIA4 | |
| SCHEMBL17090540 | 0.74 | GRIA2 (0.33) | NPY5RGLO1CKS1BSKP2GRIA4 | |
| SCHEMBL13565325 | 0.73 | GRIA1 (0.47) | GRIA1NPY5RGRIA4LMNAALDH1A1 | |
| SCHEMBL13565427 | 0.72 | GRIA1 (0.40) | GRIA1NPY5RLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |