Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACA | Q13085 | 4/20 | 0.40 |
| ▸ | ACACB | O00763 | 2/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | DUT | P33316 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565843 | 0.88 | ADRB2 (0.43) | ACACBADRB2ADRB1ADRB3 | |
| SCHEMBL11936016 | 0.85 | PPARA (0.40) | ACACANR1H4KDM5AKDM4CDUT | |
| SCHEMBL13566063 | 0.83 | ADRB2 (0.37) | ACACAACACBKDM5AKDM4CADRB2 | |
| SCHEMBL13565305 | 0.83 | HDAC4 (0.49) | DUTPARP1 | |
| SCHEMBL13105267 | 0.82 | HDAC4 (0.48) | DUTPARP1 | |
| SCHEMBL10116696 | 0.81 | NR1H4 (0.58) | NR1H4 | |
| SCHEMBL11936123 | 0.78 | NR1H4 (0.44) | NR1H4KDM5AKDM4C | |
| SCHEMBL11935831 | 0.77 | DUT (0.42) | ACACAACACBNR1H4DUTHTR1A | |
| SCHEMBL17090369 | 0.77 | ACACA (0.41) | ACACAACACBNR1H4DUT | |
| SCHEMBL13565998 | 0.77 | ACACA (0.41) | ACACAACACBNR1H4DUT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |