Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 4/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 7/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13564982 | 0.84 | GRIA1 (0.47) | GRIA1NPY5RGRIA2GRIA3CNR2 | |
| SCHEMBL13105754 | 0.83 | CNR2 (0.40) | CNR2 | |
| SCHEMBL10115519 | 0.83 | ALDH1A1 (0.46) | GRIA1KDM1AHTR1A | |
| SCHEMBL13565229 | 0.81 | GRIA1 (0.44) | GRIA1NPY5RCNR2KDM1AHTR1A | |
| SCHEMBL13565311 | 0.81 | GRIA1 (0.44) | GRIA1NPY5RCNR2KDM1AHTR1A | |
| SCHEMBL17090209 | 0.81 | GRIA1 (0.44) | GRIA1NPY5RCNR2KDM1AHTR1A | |
| SCHEMBL17090210 | 0.81 | GRIA1 (0.44) | GRIA1NPY5RCNR2KDM1AHTR1A | |
| SCHEMBL13564965 | 0.79 | POLB (0.48) | GRIA1 | |
| SCHEMBL11935707 | 0.78 | PRSS1 (0.37) | — | |
| SCHEMBL17090427 | 0.78 | QDPR (0.42) | GRIA1GRIA2GRIA3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |