Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | STK17B | O94768 | 1/20 | 0.34 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565414 | 0.84 | HTT (0.39) | GPR119CNR2ITGB3ITGA2B | |
| SCHEMBL13565661 | 0.83 | GRIA1 (0.45) | GPR119CHEK1FLT3MAOBBAZ2B | |
| SCHEMBL10113550 | 0.83 | BAZ2B (0.44) | GPR119BAZ2BMAPK14 | |
| SCHEMBL11935304 | 0.81 | ALDH1A1 (0.41) | CNR2 | |
| SCHEMBL5728560 | 0.79 | GPR119 (0.51) | GPR119CHEK1FLT3MAOBBAZ2B | |
| SCHEMBL11934983 | 0.78 | CHEK1 (0.54) | GPR119CHEK1FLT3MAOBBAZ2B | |
| SCHEMBL13565553 | 0.78 | PTPRC (0.44) | — | |
| SCHEMBL13564882 | 0.77 | CNR2 (0.44) | CNR2HSD17B10 | |
| SCHEMBL13566099 | 0.77 | CNR2 (0.40) | GPR119CNR2 | |
| SCHEMBL13565161 | 0.76 | CNR2 (0.40) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |