Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.39 |
| ▸ | STK17B | O94768 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11732033 | 0.87 | BAZ2B (0.56) | GPR119CRBNCHEK1FLT3BAZ2B | |
| SCHEMBL11934983 | 0.84 | CHEK1 (0.54) | GPR119CRBNCHEK1FLT3BAZ2B | |
| SCHEMBL13996624 | 0.83 | BAZ2B (0.49) | GPR119CHEK1FLT3BAZ2BMKNK1 | |
| SCHEMBL1931259 | 0.80 | ABL1 (0.50) | CRBNABL1HSD17B10MAPK14ADRA2A | |
| SCHEMBL13565679 | 0.79 | GPR119 (0.49) | GPR119CRBNCHEK1FLT3BAZ2B | |
| SCHEMBL13565661 | 0.79 | GRIA1 (0.45) | GPR119CRBNCHEK1FLT3BAZ2B | |
| SCHEMBL7862708 | 0.76 | ABL1 (0.42) | CRBNABL1ADRA2AAVPR2 | |
| SCHEMBL3965967 | 0.75 | PKM (0.50) | GPR119MKNK1CASP1CASP7HSD17B10 | |
| SCHEMBL6060993 | 0.75 | ALDH1A1 (0.49) | ABL1ADRA2AAVPR2 | |
| SCHEMBL7788835 | 0.75 | ABL1 (0.49) | ABL1ADRA2AAVPR2STK17BSTK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339683-B1 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO INC (US) | 2006-06-14 | — | — | EP | disclosed |
| EP-1339683-A4 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO INC (US) | 2005-07-27 | — | — | EP | disclosed |
| EP-1339683-A2 | ESTROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002041835-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2002-05-30 | — | — | WO | disclosed |