Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565780 | 0.91 | GRIA1 (0.46) | GRIA1NPY5RALDH1A1CYP2D6LMNA | |
| SCHEMBL13564793 | 0.87 | GRIA1 (0.50) | GRIA1FAAHNPY5RLMNAHTT | |
| SCHEMBL13565788 | 0.86 | GRIA1 (0.44) | GRIA1KMT2ANPY5RALDH1A1LMNA | |
| SCHEMBL13565018 | 0.85 | GRIA1 (0.43) | GRIA1NPY5RF2 | |
| SCHEMBL17090498 | 0.84 | PKM (0.47) | GRIA1NPY5RLMNAHTT | |
| SCHEMBL13565022 | 0.84 | GRIA1 (0.42) | GRIA1NPY5RMAPTHTTF2 | |
| SCHEMBL13565817 | 0.84 | THRB (0.46) | THRBFAAHKMT2AALDH1A1MAPT | |
| SCHEMBL10113825 | 0.84 | THRB (0.53) | THRBFAAHKMT2AALDH1A1NR1H4 | |
| SCHEMBL13564798 | 0.83 | GRIA1 (0.46) | GRIA1NPY5RALDH1A1LMNAHTT | |
| SCHEMBL17090496 | 0.83 | KMT2A (0.48) | GRIA1KMT2ANPY5RALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |