Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.65 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.65 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13574575 | 1.00 | PRMT5 (0.65) | PRMT5WDR77ACE2SMN1; SMN2TSHR | |
| SCHEMBL9866734 | 0.88 | PRMT5 (0.64) | PRMT5WDR77ACE2SMN1; SMN2TSHR | |
| SCHEMBL10811863 | 0.86 | PRMT5 (0.62) | PRMT5WDR77ACE2SMN1; SMN2TSHR | |
| SCHEMBL6140348 | 0.85 | PRMT5 (0.60) | PRMT5WDR77ACE2SMN1; SMN2 | |
| SCHEMBL15962433 | 0.82 | L3MBTL1 (0.75) | PRMT5WDR77ACE2SMN1; SMN2TSHR | |
| SCHEMBL13293747 | 0.81 | HRH3 (0.59) | SMN1; SMN2KDM4E | |
| SCHEMBL10868032 | 0.81 | PRMT5 (0.56) | PRMT5WDR77ACE2SMN1; SMN2TSHR | |
| SCHEMBL10806940 | 0.81 | PRMT5 (0.64) | PRMT5WDR77ACE2SMN1; SMN2TSHR | |
| SCHEMBL10504734 | 0.80 | PRMT5 (0.55) | PRMT5WDR77ACE2SMN1; SMN2KDM4E | |
| SCHEMBL10669444 | 0.80 | PRMT5 (0.55) | PRMT5WDR77ACE2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009158587-A1 | METHOD FOR TREATING PULMONARY DISEASES USING RHO KINASE INHIBITOR COMPOUNDS | INSPIRE PHARMACEUTICALS, INC. (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009155209-A1 | OPHTHALMIC FORMULATION OF RHO KINASE INHIBITOR COMPOUND | INSPIRE PHARMACEUTICALS, INC. (US) | 2009-12-23 | — | — | WO | disclosed |