Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.60 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.60 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13574575 | 0.85 | PRMT5 (0.65) | PRMT5WDR77ACE2SMN1; SMN2 | |
| SCHEMBL13574574 | 0.85 | PRMT5 (0.65) | PRMT5WDR77ACE2SMN1; SMN2 | |
| SCHEMBL9866734 | 0.84 | PRMT5 (0.64) | PRMT5WDR77ACE2SMN1; SMN2 | |
| SCHEMBL10811863 | 0.82 | PRMT5 (0.62) | PRMT5WDR77ACE2SMN1; SMN2 | |
| SCHEMBL10504734 | 0.81 | PRMT5 (0.55) | PRMT5WDR77ACE2SMN1; SMN2TDP1 | |
| SCHEMBL28508095 | 0.80 | PRMT5 (0.53) | PRMT5WDR77 | |
| SCHEMBL28508097 | 0.80 | PRMT5 (0.53) | PRMT5WDR77 | |
| SCHEMBL10670904 | 0.79 | PRMT5 (0.53) | PRMT5WDR77ACE2SMN1; SMN2ALDH1A1 | |
| SCHEMBL8562745 | 0.79 | HRH2 (0.56) | SMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL13293747 | 0.79 | HRH3 (0.59) | SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140066-A4 | NITROSATED AND NITROSYLATED H2 RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS AND METHODS OF USE | NITROMED INC (US) | 2005-11-09 | — | — | EP | disclosed |
| EP-1140066-A1 | NITROSATED AND NITROSYLATED H2 RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Nitromed, Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000028988-A1 | NITROSATED AND NITROSYLATED H2 RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS AND METHODS OF USE | NITROMED, INC. (US) | 2000-05-25 | — | — | WO | disclosed |