Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glutamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 2/20 | 0.82 |
| ▸ | GRM6 | O15303 | 2/20 | 0.82 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.82 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.82 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.82 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.82 |
| ▸ | GSR | P00390 | 1/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.82 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.82 |
| ▸ | GRM5 | P41594 | 1/20 | 0.82 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.82 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.82 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.82 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.82 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.82 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.82 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.82 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.82 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.82 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL7430337 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL17184331 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL1661037 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL247753 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL418133 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL8007972 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL6528977 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL16584589 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL17184330 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL9817837 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2821 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240197900-A1 | DISACCHARIDE LINKER, DISACCHARIDE-SMALL MOLECULE DRUG CONJUGATE AND SUGAR CHAIN FIXED-POINT ANTIBODY-DRUG CONJUGATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2024-06-20 | — | — | US | claimed |
| EP-4279089-A1 | DISACCHARIDE LINKER, DISACCHARIDE-SMALL MOLECULE DRUG CONJUGATE AND SUGAR CHAIN FIXED-POINT ANTIBODY-DRUG CONJUGATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2023-11-22 | — | — | EP | claimed |
| WO-2023097038-A1 | CLEAVABLE RADIOLIGANDS FOR TARGETING CELL SURFACE RECEPTORS AND USES THEREOF | FULL-LIFE TECHNOLOGIES U.S. INC. (US) | 2023-06-01 | — | — | WO | claimed |
| WO-2022256643-A1 | TISSUE-ENGINEERED ROSTRAL MIGRATORY STREAM FOR NEURONAL REPLACEMENT | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2022-12-08 | — | — | WO | claimed |
| CN-112725803-B | Titanium etching solution for wafer level packaging | 江苏奥首材料科技有限公司 | 2022-11-15 | — | — | CN | claimed |
| CN-114949236-A | Disaccharide linker, disaccharide-small molecule drug conjugate, and sugar chain-site-directed antibody-drug conjugate, and preparation method and application thereof | 中国科学院上海药物研究所 | 2022-08-30 | — | — | CN | claimed |
| US-11390890-B2 | Dibasic organic acid producing strain and preparation and application of same | TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCES (CN) | 2022-07-19 | — | — | US | claimed |
| CN-113647359-A | Construction method of tunicamycin injection induced acute liver injury mouse model | 芜湖职业技术学院 | 2021-11-16 | — | — | CN | claimed |
| CN-111848722-B | Tripterine derivative and preparation method and application thereof | 澳门科技大学 | 2021-11-02 | — | — | CN | claimed |
| EP-3274709-B1 | METHODS OF PROGNOSING MILD TRAUMATIC BRAIN INJURIES | TRANSLATIONAL GENOMICS RES INST (US) | 2021-07-07 | — | — | EP | claimed |
| EP-0759750-A4 | COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES | SHAPIRO HOWARD K (US) | 1998-05-27 | — | — | EP | claimed |
| US-5739273-A | CONJUGATED BACTERIORHODOPSIN FOR DRUG DELIVERY | YALE UNIVERSITY (US) | 1998-04-14 | — | — | US | claimed |
| EP-0759750-A1 | COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES | SHAPIRO, Howard, K. (US) | 1997-03-05 | — | — | EP | claimed |
| WO-1995031194-A1 | COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES | SHAPIRO HOWARD K (US) | 1995-11-23 | — | — | WO | claimed |
| EP-0564561-A4 | PEPTIDES KETOAMIDES, KETOACIDS, AND KETOESTERS | GEORGIA TECH RES INST (US) | 1994-08-10 | — | — | EP | claimed |
| EP-0564561-A1 | PEPTIDES KETOAMIDES, KETOACIDS, AND KETOESTERS | GEORGIA TECH RESEARCH CORPORATION (US) | 1993-10-13 | — | — | EP | claimed |
| EP-0548228-A1 | LIPASE VARIANTS | NOVO NORDISK A/S (DK) | 1993-06-30 | — | — | EP | claimed |
| WO-1992012140-A1 | PEPTIDES KETOAMIDES, KETOACIDS, AND KETOESTERS | GEORGIA TECH RESEARCH CORPORATION (US) | 1992-07-23 | — | — | WO | claimed |
| WO-1992005249-A1 | LIPASE VARIANTS | NOVO NORDISK A/S (DK) | 1992-04-02 | — | — | WO | claimed |
| US-4488989-A | ESTERS, DETERGENTS, STORAGE STABILITY | LEVER BROTHERS COMPANY (US) | 1984-12-18 | — | — | US | claimed |