Glutamic Acid

Glutamic Acid

SCHEMBL135757

N[C@@H](CC(=O)O)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SSTR1SSTR2SSTR3SSTR5

The experimentally established mechanism targets of Glutamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM8 O00222 2/20 0.82
GRM6 O15303 2/20 0.82
GRM7 Q14831 2/20 0.82
GRM4 Q14833 2/20 0.82
GRIN2D O15399 1/20 0.82
GRIN3B O60391 1/20 0.82
GSR P00390 1/20 0.82
CYP1A2 P05177 1/20 0.82
GRIK1 P39086 1/20 0.82
GRM5 P41594 1/20 0.82
GRIA1 P42261 1/20 0.82
GRIA2 P42262 1/20 0.82
GRIA3 P42263 1/20 0.82
SLC1A3 P43003 1/20 0.82
SLC1A2 P43004 1/20 0.82
SLC1A1 P43005 1/20 0.82
GRIA4 P48058 1/20 0.82
GRIN1 Q05586 1/20 0.82
GRIN2A Q12879 1/20 0.82
GRIK2 Q13002 1/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
D-Glutamate SCHEMBL7430337 1.00 GRM8 (0.82) GRM8GRM6GRM7GRM4GRIN2D
D-Glutamate SCHEMBL17184330 1.00 GRM8 (0.82) GRM8GRM6GRM7GRM4GRIN2D
Glutamic Acid SCHEMBL8007972 1.00 GRM8 (0.82) GRM8GRM6GRM7GRM4GRIN2D
Glutamic Acid SCHEMBL6528977 1.00 GRM8 (0.82) GRM8GRM6GRM7GRM4GRIN2D
Glutamic Acid SCHEMBL17184331 1.00 GRM8 (0.82) GRM8GRM6GRM7GRM4GRIN2D
Glutamic Acid SCHEMBL1661037 1.00 GRM8 (0.82) GRM8GRM6GRM7GRM4GRIN2D
D-Glutamate SCHEMBL247753 1.00 GRM8 (0.82) GRM8GRM6GRM7GRM4GRIN2D
D-Glutamate SCHEMBL418133 1.00 GRM8 (0.82) GRM8GRM6GRM7GRM4GRIN2D
Glutamic Acid SCHEMBL16584589 1.00 GRM8 (0.82) GRM8GRM6GRM7GRM4GRIN2D
D-Glutamate SCHEMBL9817837 1.00 GRM8 (0.82) GRM8GRM6GRM7GRM4GRIN2D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2821 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240197900-A1 DISACCHARIDE LINKER, DISACCHARIDE-SMALL MOLECULE DRUG CONJUGATE AND SUGAR CHAIN FIXED-POINT ANTIBODY-DRUG CONJUGATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) 2024-06-20 US claimed
EP-4279089-A1 DISACCHARIDE LINKER, DISACCHARIDE-SMALL MOLECULE DRUG CONJUGATE AND SUGAR CHAIN FIXED-POINT ANTIBODY-DRUG CONJUGATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) 2023-11-22 EP claimed
WO-2023097038-A1 CLEAVABLE RADIOLIGANDS FOR TARGETING CELL SURFACE RECEPTORS AND USES THEREOF FULL-LIFE TECHNOLOGIES U.S. INC. (US) 2023-06-01 WO claimed
WO-2022256643-A1 TISSUE-ENGINEERED ROSTRAL MIGRATORY STREAM FOR NEURONAL REPLACEMENT THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2022-12-08 WO claimed
CN-112725803-B Titanium etching solution for wafer level packaging 江苏奥首材料科技有限公司 2022-11-15 CN claimed
CN-114949236-A Disaccharide linker, disaccharide-small molecule drug conjugate, and sugar chain-site-directed antibody-drug conjugate, and preparation method and application thereof 中国科学院上海药物研究所 2022-08-30 CN claimed
US-11390890-B2 Dibasic organic acid producing strain and preparation and application of same TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCES (CN) 2022-07-19 US claimed
CN-113647359-A Construction method of tunicamycin injection induced acute liver injury mouse model 芜湖职业技术学院 2021-11-16 CN claimed
CN-111848722-B Tripterine derivative and preparation method and application thereof 澳门科技大学 2021-11-02 CN claimed
EP-3274709-B1 METHODS OF PROGNOSING MILD TRAUMATIC BRAIN INJURIES TRANSLATIONAL GENOMICS RES INST (US) 2021-07-07 EP claimed
EP-0759750-A4 COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES SHAPIRO HOWARD K (US) 1998-05-27 EP claimed
US-5739273-A CONJUGATED BACTERIORHODOPSIN FOR DRUG DELIVERY YALE UNIVERSITY (US) 1998-04-14 US claimed
EP-0759750-A1 COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES SHAPIRO, Howard, K. (US) 1997-03-05 EP claimed
WO-1995031194-A1 COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES SHAPIRO HOWARD K (US) 1995-11-23 WO claimed
EP-0564561-A4 PEPTIDES KETOAMIDES, KETOACIDS, AND KETOESTERS GEORGIA TECH RES INST (US) 1994-08-10 EP claimed
EP-0564561-A1 PEPTIDES KETOAMIDES, KETOACIDS, AND KETOESTERS GEORGIA TECH RESEARCH CORPORATION (US) 1993-10-13 EP claimed
EP-0548228-A1 LIPASE VARIANTS NOVO NORDISK A/S (DK) 1993-06-30 EP claimed
WO-1992012140-A1 PEPTIDES KETOAMIDES, KETOACIDS, AND KETOESTERS GEORGIA TECH RESEARCH CORPORATION (US) 1992-07-23 WO claimed
WO-1992005249-A1 LIPASE VARIANTS NOVO NORDISK A/S (DK) 1992-04-02 WO claimed
US-4488989-A ESTERS, DETERGENTS, STORAGE STABILITY LEVER BROTHERS COMPANY (US) 1984-12-18 US claimed