Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glutamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 2/20 | 0.82 |
| ▸ | GRM6 | O15303 | 2/20 | 0.82 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.82 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.82 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.82 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.82 |
| ▸ | GSR | P00390 | 1/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.82 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.82 |
| ▸ | GRM5 | P41594 | 1/20 | 0.82 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.82 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.82 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.82 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.82 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.82 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.82 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.82 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.82 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.82 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL7430337 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL17184330 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL8007972 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL17184331 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL135757 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL1661037 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL247753 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL418133 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL16584589 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL9817837 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109640954-B | Liquid formulations containing botulinum toxin and stabilizers and methods of making same | 秀杰股份公司 | 2021-05-28 | — | — | CN | disclosed |
| CN-109640954-A | Liquid preparation and preparation method thereof containing botulin toxin and stabilizer | AB生物科技股份有限公司 | 2019-04-16 | — | — | CN | disclosed |
| US-20050004351-A1 | Therapeutic and diagnostic domain 1 beta2GP1 polypeptides and methods of using same | MARQUIS DAVID M (US) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004351-A1 | Therapeutic and diagnostic domain 1 beta2GP1 polypeptides and methods of using same | PLTP, PA2G4, PAG1 | GRM8 3250/4885GRM6 3672/4885GRM7 3171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.