Known targets — ChEMBL curated mechanism
SLC6A2SLC6A3SSTR1SSTR2SSTR3SSTR5
The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 2/20 | 0.82 |
| ▸ | GRM6 | O15303 | 2/20 | 0.82 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.82 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.82 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.82 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.82 |
| ▸ | GSR | P00390 | 1/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.82 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.82 |
| ▸ | GRM5 | P41594 | 1/20 | 0.82 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.82 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.82 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.82 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.82 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.82 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.82 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.82 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.82 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.82 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL7430337 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL17184330 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL8007972 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL6528977 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL17184331 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL135757 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL1661037 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL247753 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL16584589 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL9817837 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11903708-B2 | Switchable low voltage electrochemical sensing for interfering species rejection | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2024-02-20 | — | — | US | claimed |
| EP-3688450-A1 | METHOD OF PRODUCING THIN ENZYME-BASED SENSING LAYERS ON PLANAR SENSORS | California Institute of Technology (US) | 2020-08-05 | — | — | EP | claimed |
| WO-2019067684-A1 | SWITCHABLE LOW VOLTAGE ELECTROCHEMICAL SENSING FOR INTERFERING SPECIES REJECTION | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2019-04-04 | — | — | WO | claimed |
| WO-2019067681-A1 | METHOD OF PRODUCING THIN ENZYME-BASED SENSING LAYERS ON PLANAR SENSORS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2019-04-04 | — | — | WO | claimed |
| US-20190090796-A1 | METHOD OF PRODUCING THIN ENZYME-BASED SENSING LAYERS ON PLANAR SENSORS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2019-03-28 | — | — | US | claimed |
| US-20190090797-A1 | SWITCHABLE LOW VOLTAGE ELECTROCHEMICAL SENSING FOR INTERFERING SPECIES REJECTION | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2019-03-28 | — | — | US | claimed |
| US-9468402-B2 | Tissue implantable microbiosensor | PINNACLE TECHNOLOGY, INC. (US) | 2016-10-18 | — | — | US | claimed |
| US-20130324820-A1 | TISSUE IMPLANTABLE MICROBIOSENSOR | PINNACLE TECHNOLOGY, INC. (US) | 2013-12-05 | — | — | US | claimed |
| US-20130172705-A1 | ENZYME CO-FACTOR ENHANCEMENT OF BIOSENSOR PERFORMANCE | PINNACLE TECHNOLOGY, INC. (US) | 2013-07-04 | — | — | US | claimed |
| WO-2013008900-A1 | METHODS AND KITS FOR DECREASING INTERFERENCES FROM LEUKOCYTES IN SPECIFIC BINDING ASSAYS | ABBOTT JAPAN CO. LTD. (JP) | 2013-01-17 | — | — | WO | claimed |
| WO-2011068681-A1 | ASSAY FOR CARDIAC TROPONIN-T (cTnT) | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | claimed |
| WO-2011068680-A1 | ASSAY FOR DIAGNOSIS OF CARDIAC MYOCYTE DAMAGE | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | claimed |
| US-20110129854-A1 | ASSAY FOR DIAGNOSIS OF CARDIAC MYOCYTE DAMAGE | ABBOTT LABORATORIES (US) | 2011-06-02 | — | — | US | claimed |
| US-20110129818-A1 | ASSAY FOR CARDIAC TROPONIN-T (cTnT) | ABBOTT LABORATORIES (US) | 2011-06-02 | — | — | US | claimed |
| WO-2009076331-A1 | INTERDEPENDENT ASSAYS FOR DETECTING TWO OR MORE ANALYTES OF INTEREST IN A TEST SAMPLE | ABBOTT LABORATORIES (US) | 2009-06-18 | — | — | WO | claimed |
| US-20090148871-A1 | Interdependent Assays for Detecting Two or More Analytes of Interest in A Test Sample | ABBOTT LABORATORIES | 2009-06-11 | — | — | US | claimed |
| WO-2009026401-A1 | HOMOGENEOUS CHEMILUMINESCENT IMMUNOASSAY FOR ANALYSIS OF IRON METALLOPROTEINS | ABBOTT LABORATORIES (US) | 2009-02-26 | — | — | WO | claimed |
| WO-2009026402-A1 | MEASUREMENT OF HALOPEROXIDASE ACTIVITY WITH CHEMILUMINESCENT DETECTION | ABBOTT LABORATORIES (US) | 2009-02-26 | — | — | WO | claimed |
| WO-2008124749-A1 | ACRIDINIUM PHENYL ESTERS USEFUL IN THE ANALYSIS OF BIOLOGICAL SAMPLES | ABBOTT LABORATORIES (US) | 2008-10-16 | — | — | WO | claimed |
| US-20080248493-A1 | ACRIDINIUM PHENYL ESTERS USEFUL IN THE ANALYSIS OF BIOLOGICAL SAMPLES | ABBOTT LABORATORIES | 2008-10-09 | — | — | US | claimed |