Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 2/20 | 0.82 |
| ▸ | GRM6 | O15303 | 2/20 | 0.82 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.82 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.82 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.82 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.82 |
| ▸ | GSR | P00390 | 1/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.82 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.82 |
| ▸ | GRM5 | P41594 | 1/20 | 0.82 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.82 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.82 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.82 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.82 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.82 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.82 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.82 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.82 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.82 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL7430337 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL17184331 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL1661037 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL135757 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL418133 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL8007972 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL6528977 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| Glutamic Acid SCHEMBL16584589 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL17184330 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D | |
| D-Glutamate SCHEMBL9817837 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1489 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022256643-A1 | TISSUE-ENGINEERED ROSTRAL MIGRATORY STREAM FOR NEURONAL REPLACEMENT | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2022-12-08 | — | — | WO | claimed |
| US-11390890-B2 | Dibasic organic acid producing strain and preparation and application of same | TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCES (CN) | 2022-07-19 | — | — | US | claimed |
| CN-113647359-A | Construction method of tunicamycin injection induced acute liver injury mouse model | 芜湖职业技术学院 | 2021-11-16 | — | — | CN | claimed |
| EP-3274709-B1 | METHODS OF PROGNOSING MILD TRAUMATIC BRAIN INJURIES | TRANSLATIONAL GENOMICS RES INST (US) | 2021-07-07 | — | — | EP | claimed |
| WO-2021032271-A1 | INDUCTION OF FUNCTIONAL ASTROCYTES FROM PLURIPOTENT STEM CELLS | LU LICENSE AB (SE) | 2021-02-25 | — | — | WO | claimed |
| US-20200347415-A1 | DIBASIC ORGANIC ACID PRODUCING STRAIN AND PREPARATION AND APPLICATION OF SAME | TIANJIN INST IND BIOTECHNOLOGY CAS (CN) | 2020-11-05 | — | — | US | claimed |
| WO-2019191650-A1 | COMPOSITIONS AND METHODS FOR TARGETING CELLS | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2019-10-03 | — | — | WO | claimed |
| US-20190241899-A1 | Methods of Crispr Mediated Genome Modulation in V. Natriegens | UNITED STATES DEPARTMENT OF ENERGY | 2019-08-08 | — | — | US | claimed |
| EP-3501511-A1 | MEANS FOR PREVENTING AND TREATING BRAIN METASTASIS | Fundación Centro Nacional De Investigaciones Oncológicas Carlos III (ES) | 2019-06-26 | — | — | EP | claimed |
| US-20190160188-A1 | Radiolabeled Alpha-Melanocyte Stimulating Hormone Hybrid Peptide for Melanoma Targeting | STC UNM (US) | 2019-05-30 | — | — | US | claimed |
| US-5739273-A | CONJUGATED BACTERIORHODOPSIN FOR DRUG DELIVERY | YALE UNIVERSITY (US) | 1998-04-14 | — | — | US | claimed |
| EP-0759750-A1 | COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES | SHAPIRO, Howard, K. (US) | 1997-03-05 | — | — | EP | claimed |
| WO-1995031194-A1 | COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES | SHAPIRO HOWARD K (US) | 1995-11-23 | — | — | WO | claimed |
| EP-0564561-A4 | PEPTIDES KETOAMIDES, KETOACIDS, AND KETOESTERS | GEORGIA TECH RES INST (US) | 1994-08-10 | — | — | EP | claimed |
| EP-0564561-A1 | PEPTIDES KETOAMIDES, KETOACIDS, AND KETOESTERS | GEORGIA TECH RESEARCH CORPORATION (US) | 1993-10-13 | — | — | EP | claimed |
| EP-0548228-A1 | LIPASE VARIANTS | NOVO NORDISK A/S (DK) | 1993-06-30 | — | — | EP | claimed |
| WO-1992012140-A1 | PEPTIDES KETOAMIDES, KETOACIDS, AND KETOESTERS | GEORGIA TECH RESEARCH CORPORATION (US) | 1992-07-23 | — | — | WO | claimed |
| WO-1992005249-A1 | LIPASE VARIANTS | NOVO NORDISK A/S (DK) | 1992-04-02 | — | — | WO | claimed |
| CN-1043134-A | ANTICOAGULANT PEPTIDES | MERRELL DOW PHARMA (US) | 1990-06-20 | — | — | CN | claimed |
| US-4488989-A | ESTERS, DETERGENTS, STORAGE STABILITY | LEVER BROTHERS COMPANY (US) | 1984-12-18 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190160188-A1 | Radiolabeled Alpha-Melanocyte Stimulating Hormone Hybrid Peptide for Melanoma Targeting | MC1R, MC3R, MC4R | GRM8 4271/4885GRM6 3964/4885GRM7 3424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.