Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELOVL1 | Q9BW60 | 2/20 | 0.72 |
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31496767 | 0.89 | HDAC1 (0.70) | ELOVL1MAPTMAPK1HDAC3HDAC4 | |
| SCHEMBL3255629 | 0.88 | WNT3A (0.69) | MAPTHDAC1HDAC2ALDH1A1MEN1 | |
| SCHEMBL6610860 | 0.87 | ABL1 (0.70) | MAPTMAPK1NPC1USP2ALDH1A1 | |
| SCHEMBL225327 | 0.87 | ELOVL1 (0.74) | ELOVL1MAPTMAPK1HDAC3HDAC4 | |
| SCHEMBL11790758 | 0.86 | ALDH1A1 (0.69) | MAPTMAPK1HDAC3HDAC4HDAC1 | |
| SCHEMBL28643881 | 0.86 | HDAC1 (0.66) | MAPTMAPK1HDAC1HDAC9NPC1 | |
| SCHEMBL8402291 | 0.85 | MAPT (0.73) | ELOVL1MAPTMAPK1HDAC3HDAC4 | |
| SCHEMBL2452315 | 0.85 | ELOVL1 (0.72) | ELOVL1MAPTMAPK1HDAC3HDAC4 | |
| SCHEMBL21224224 | 0.85 | ELOVL1 (0.72) | ELOVL1MAPTMAPK1HDAC3HDAC4 | |
| SCHEMBL19380614 | 0.84 | ELOVL1 (1.00) | ELOVL1MAPTMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10611733-B2 | Quinazolinone analogs and use of quinazolinone analogs for treating or preventing certain viral infections | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2020-04-07 | — | — | US | disclosed |
| EP-3424912-A1 | 2-AMINOTHIAZOLE DERIVATIVES FOR MEDICAL USE | Huazhong University of Science and Technology (CN) | 2019-01-09 | — | — | EP | disclosed |
| US-9771340-B2 | 2-aminothiazole derivatives and methods of preparing and using the same | WUHAN INNAMUNE PHARMACEUTICAL CO., LTD. (CN) | 2017-09-26 | — | — | US | disclosed |
| US-20170144978-A1 | QUINAZOLINONE ANALOGS AND USE OF QUINAZOLINONE ANALOGS FOR TREATING OR PREVENTING CERTAIN VIRAL INFECTIONS | SOUTHERN RESEARCH INSTITUTE | 2017-05-25 | — | — | US | disclosed |
| US-20170144978-A1 | QUINAZOLINONE ANALOGS AND USE OF QUINAZOLINONE ANALOGS FOR TREATING OR PREVENTING CERTAIN VIRAL INFECTIONS | SOUTHERN RESEARCH INSTITUTE | 2017-05-25 | — | — | US | disclosed |
| US-9598402-B2 | Quinazolinone analogs and use of quinazolinone analogs for treating or preventing certain viral infections | SOUTHERN RESEARCH INSTITUTE (US) | 2017-03-21 | — | — | US | disclosed |
| US-9598402-B2 | Quinazolinone analogs and use of quinazolinone analogs for treating or preventing certain viral infections | SOUTHERN RESEARCH INSTITUTE (US) | 2017-03-21 | — | — | US | disclosed |
| EP-2744787-B1 | QUINAZOLINONE ANALOGS AND USE OF QUINAZOLINONE ANALOGS FOR TREATING OR PREVENTING CERTAIN VIRAL INFECTIONS | SOUTHERN RES INST (US) | 2016-11-02 | — | — | EP | disclosed |
| CN-102336720-B | Thiazolamine derivative and preparation method and application | HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2016-01-13 | — | — | CN | disclosed |
| US-20140256753-A1 | QUINAZOLINONE ANALOGS AND USE OF QUINAZOLINONE ANALOGS FOR TREATING OR PREVENTING CERTAIN VIRAL INFECTIONS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2014-09-11 | — | — | US | disclosed |
| EP-2682390-A1 | 2-AMINOTHIAZOLE DERIVATIVE, PREPARATION METHOD, AND USE | Huazhong University of Science and Technology (CN) | 2014-01-08 | — | — | EP | disclosed |
| US-20140004155-A1 | 2-AMINOTHIAZOLE DERIVATIVES AND METHODS OF PREPARING AND USING THE SAME | HANGZHOU ZHONGMEI HUADONG PHARMACEUTICAL CO., LTD. (CN) | 2014-01-02 | — | — | US | disclosed |
| US-8481577-B2 | Amide thiazole derivative, preparation method and uses thereof | TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH (CN) | 2013-07-09 | — | — | US | disclosed |
| EP-2404909-B1 | AMIDE THIAZOLE DERIVATIVE, PREPARATION METHOD AND USES THEREOF | TIANJIN INST PHARM RESEARCH (CN) | 2013-05-29 | — | — | EP | disclosed |
| WO-2013025508-A1 | QUINAZOLINONE ANALOGS AND USE OF QUINAZOLINONE ANALOGS FOR TREATING OR PREVENTING CERTAIN VIRAL INFECTIONS | SOUTHERN RESEARCH INSTITUTE (US) | 2013-02-21 | — | — | WO | disclosed |
| WO-2013025508-A1 | QUINAZOLINONE ANALOGS AND USE OF QUINAZOLINONE ANALOGS FOR TREATING OR PREVENTING CERTAIN VIRAL INFECTIONS | SOUTHERN RESEARCH INSTITUTE (US) | 2013-02-21 | — | — | WO | disclosed |
| CN-102351854-A | Amino thiazole derivative and preparation method and medical purpose thereof | UNIV HUAZHONG SCIENCE TECH | 2012-02-15 | — | — | CN | disclosed |
| CN-102336720-A | 2-aminothiazole derivatives, and preparation method and application thereof | UNIV HUAZHONG SCIENCE TECH | 2012-02-01 | — | — | CN | disclosed |
| EP-2404909-A1 | AMIDE THIAZOLE DERIVATIVE, PREPARATION METHOD AND USES THEREOF | Tianjin Institute Of Pharmaceutical Research (CN) | 2012-01-11 | — | — | EP | disclosed |
| US-20110281922-A1 | AMIDE THIAZOLE DERIVATIVE, PREPARATION METHOD AND USES THEREOF | TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH (CN) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281922-A1 | AMIDE THIAZOLE DERIVATIVE, PREPARATION METHOD AND USES THEREOF | DPP4, DPP3, DPP7 | ELOVL1 1900/4885MAPT 2411/4885MAPK1 2719/4885 |
| US-20140256753-A1 | QUINAZOLINONE ANALOGS AND USE OF QUINAZOLINONE ANALOGS FOR TREATING OR PREVENTING CERTAIN VIRAL INFECTIONS | HAVCR2, EIF2AK2, GLS2 | ELOVL1 2457/4885MAPT 1316/4885MAPK1 1937/4885 |
| US-20170144978-A1 | QUINAZOLINONE ANALOGS AND USE OF QUINAZOLINONE ANALOGS FOR TREATING OR PREVENTING CERTAIN VIRAL INFECTIONS | ZC3HAV1, EIF2AK2, GTF3C3 | ELOVL1 2179/4885MAPT 1974/4885MAPK1 2987/4885 |
| US-10611733-B2 | Quinazolinone analogs and use of quinazolinone analogs for treating or preventing certain viral infections | ZC3HAV1, EIF2AK2, GTF3C3 | ELOVL1 2179/4885MAPT 1974/4885MAPK1 2987/4885 |
| US-20140004155-A1 | 2-AMINOTHIAZOLE DERIVATIVES AND METHODS OF PREPARING AND USING THE SAME | CCNT1, CCNE1, CCNT2 | ELOVL1 3796/4885MAPT 1485/4885MAPK1 2273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.