Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PHGDH | O43175 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5522482 | 0.80 | SMN1; SMN2 (0.36) | HPGDPRKDCTSHRPOLBMAPT | |
| SCHEMBL11732309 | 0.72 | TERT (0.41) | HPGDPRKDCTSHRMAPTSMN1; SMN2 | |
| SCHEMBL10917858 | 0.72 | GAA (0.44) | HPGDPRKDCPOLBMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10944244 | 0.71 | GAA (0.43) | HPGDPRKDCMAPTSMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL11732394 | 0.70 | TERT (0.39) | HPGDTSHRPOLBMAPTSMN1; SMN2 | |
| SCHEMBL5519260 | 0.68 | POLB (0.35) | TSHRPOLBKMT2ALMNA | |
| SCHEMBL6799570 | 0.67 | SMN1; SMN2 (0.35) | HPGDTSHRPOLBMAPTSMN1; SMN2 | |
| SCHEMBL27531202 | 0.67 | HRH3 (0.40) | HPGDMAPTSMN1; SMN2RAB9AKMT2A | |
| SCHEMBL541488 | 0.66 | LMNA (0.47) | PRKDCTSHRMAPTAKR1C3SMN1; SMN2 | |
| SCHEMBL8779695 | 0.65 | ALDH1A1 (0.50) | HPGDTSHRPOLBMAPTAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338412-B2 | Inhibitors of P38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-12-25 | — | — | US | claimed |
| EP-1309560-B1 | Pyridine derivatives as inhibitors of p38 | VERTEX PHARMA (US) | 2012-10-03 | — | — | EP | claimed |
| US-20110281878-A1 | INHIBITORS OF p38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-11-17 | — | — | US | claimed |
| US-20110160163-A1 | INHIBITORS OF p38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-30 | — | — | US | claimed |
| EP-2336111-A1 | Heterocyclic inhibitors of p38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-22 | — | — | EP | claimed |
| US-7951809-B2 | Inhibitors of p38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-05-31 | — | — | US | claimed |
| US-7919513-B2 | Inhibitors of p38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-04-05 | — | — | US | claimed |
| US-20090318452-A1 | INHIBITORS OF p38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-12-24 | — | — | US | claimed |
| US-7598277-B2 | Inhibitors of p38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-10-06 | — | — | US | claimed |
| EP-2062879-A1 | Heterocyclic inhibitors of p38 | Vertex Pharmceuticals Incorporated (US) | 2009-05-27 | — | — | EP | claimed |
| WO-2001070695-A1 | PYRIDINE DERIVATIVES AS INHIBITORS OF P38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2001-09-27 | — | — | WO | claimed |
| CN-1306512-A | Heterocyclic inhibitors of P38 | VERTEX PHARMA (US) | 2001-08-01 | — | — | CN | claimed |
| EP-1114039-A1 | INHIBITORS OF p38 | Vertex Pharmaceuticals Incorporated (US) | 2001-07-11 | — | — | EP | claimed |
| EP-1086085-A1 | INHIBITORS OF p38 | Vertex Pharmaceuticals Incorporated (US) | 2001-03-28 | — | — | EP | claimed |
| EP-1077943-A1 | HETEROCYCLIC INHIBITORS OF P38 | Vertex Pharmaceuticals Incorporated (US) | 2001-02-28 | — | — | EP | claimed |
| WO-2000017175-A1 | INHIBITORS OF p38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2000-03-30 | — | — | WO | claimed |
| WO-1999064400-A1 | INHIBITORS OF p38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1999-12-16 | — | — | WO | claimed |
| WO-1999058502-A1 | HETEROCYCLIC INHIBITORS OF P38 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1999-11-18 | — | — | WO | claimed |
| EP-0951467-A1 | SUBSTITUTED NITROGEN CONTAINING HETEROCYCLES AS INHIBITORS OF p38 PROTEIN KINASE | Vertex Pharmaceuticals Incorporated (US) | 1999-10-27 | — | — | EP | claimed |
| WO-1998027098-A1 | SUBSTITUTED NITROGEN CONTAINING HETEROCYCLES AS INHIBITORS OF p38 PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1998-06-25 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160163-A1 | INHIBITORS OF p38 | ZAP70, MAPK1, MAP3K20 | HPGD 2180/4885PRKDC 71/4885TSHR 3685/4885 |
| US-20110281878-A1 | INHIBITORS OF p38 | MAPK1, MAPK3, MAP3K1 | HPGD 1371/4885PRKDC 165/4885TSHR 3750/4885 |
| US-20090318452-A1 | INHIBITORS OF p38 | ZAP70, MAPK1, MAP3K20 | HPGD 2180/4885PRKDC 71/4885TSHR 3685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.