Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MAT2A | P31153 | 1/20 | 0.54 |
| ▸ | FABP3 | P05413 | 1/20 | 0.54 |
| ▸ | FABP4 | P15090 | 1/20 | 0.54 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | DHODH | Q02127 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13585806 | 0.82 | KDM4E (0.58) | KDM4EMAT2AFABP3FABP4FABP5 | |
| SCHEMBL24109078 | 0.79 | MAPT (0.54) | KDM4EMAT2AFABP3FABP4FABP5 | |
| SCHEMBL13585117 | 0.77 | KDM4E (0.58) | KDM4EMAT2AFABP3FABP4MAPK1 | |
| SCHEMBL24108915 | 0.76 | DHODH (0.58) | KDM4EMAT2AFABP3FABP4MAPK1 | |
| SCHEMBL24109079 | 0.75 | MAT2A (0.50) | KDM4EMAT2AFABP3FABP4FABP5 | |
| SCHEMBL24108921 | 0.74 | MAPT (0.61) | KDM4EMAT2AMAPK1DHODHGAA | |
| SCHEMBL24108917 | 0.74 | POLB (0.60) | KDM4EMAT2AMAPK1DHODHGAA | |
| SCHEMBL24108920 | 0.74 | MAPT (0.54) | KDM4EMAT2AMAPK1DHODHGAA | |
| SCHEMBL26314747 | 0.74 | KDM4E (0.55) | KDM4EMAT2AFABP3FABP4FABP5 | |
| SCHEMBL24109317 | 0.74 | MAT2A (0.61) | KDM4EMAT2AMAPK1DHODHGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273012-B2 | Facile preparation of 4-substituted quinazolines and related heterocycles | UNIVERSITY OF HOUSTON SYSTEM (US) | 2016-03-01 | — | — | US | disclosed |
| US-20120283436-A1 | FACILE PREPARATION OF 4-SUBSTITUTED QUINAZOLINES AND RELATED HETEROCYCLES | THE UNIVERSITY OF HOUSTON (US) | 2012-11-08 | — | — | US | disclosed |
| WO-2012151141-A2 | A FACILE PREPARATION OF 4-SUBSTITUTED QUINAZOLINES AND RELATED HETEROCYCLES | UNIVERSITY OF HOUSTON SYSTEM (US) | 2012-11-08 | — | — | WO | disclosed |