Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | MAT2A | P31153 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13585806 | 0.80 | KDM4E (0.58) | MAPTKDM4EGAAMAT2ATP53 | |
| SCHEMBL13585646 | 0.79 | KDM4E (0.54) | MAPTKDM4EGAAMAT2ATP53 | |
| SCHEMBL31218561 | 0.75 | ALDH1A1 (0.69) | MAPTKDM4EGAATP53MAPK1 | |
| SCHEMBL24108921 | 0.74 | MAPT (0.61) | MAPTKDM4EGAAMAT2ATP53 | |
| SCHEMBL13585117 | 0.74 | KDM4E (0.58) | MAPTKDM4EGAAMAT2ATP53 | |
| SCHEMBL24108920 | 0.74 | MAPT (0.54) | MAPTKDM4EGAAMAT2ATP53 | |
| SCHEMBL3486575 | 0.74 | KDM4E (0.71) | MAPTKDM4EGAAMAT2ATP53 | |
| SCHEMBL3867555 | 0.73 | KDM4E (0.54) | MAPTKDM4EGAAMAT2ATP53 | |
| SCHEMBL24109079 | 0.73 | MAT2A (0.50) | MAPTKDM4EGAAMAT2ATP53 | |
| SCHEMBL13585302 | 0.72 | MAPK1 (0.65) | MAPTKDM4EGAAMAT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252680-A1 | 4-ARYLQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2021-12-16 | — | — | WO | disclosed |