Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | HCN1 | O60741 | 8/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | HCN4 | Q9Y3Q4 | 4/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12342527 | 0.90 | TP53 (0.56) | TP53LMNATHRBHCN1MEN1 | |
| Hydrochloric Acid SCHEMBL2361490 | 0.89 | TP53 (0.55) | TP53LMNATHRBHCN1MEN1 | |
| SCHEMBL13587277 | 0.87 | TP53 (0.53) | TP53LMNATHRBHCN1MEN1 | |
| SCHEMBL4374590 | 0.78 | TP53 (0.58) | TP53LMNATHRBHCN1MEN1 | |
| SCHEMBL4379695 | 0.77 | HCN1 (0.46) | TP53LMNATHRBHCN1MEN1 | |
| SCHEMBL3405602 | 0.76 | HCN1 (0.47) | TP53LMNATHRBHCN1MEN1 | |
| Hydrochloric Acid SCHEMBL3405749 | 0.75 | HCN1 (0.46) | TP53LMNATHRBHCN1MEN1 | |
| SCHEMBL2989541 | 0.73 | CYP2D6 (0.67) | LMNAKMT2AHTTPOLB | |
| SCHEMBL16233241 | 0.72 | TP53 (1.00) | TP53LMNATHRBHCN1MEN1 | |
| SCHEMBL16233200 | 0.71 | TP53 (0.81) | TP53LMNATHRBHCN1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8541573-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2013-09-24 | — | — | US | disclosed |
| US-20090298812-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298812-A1 | Substituted Sulfonamide Compounds | BDKRB1, BDKRB2, TRPV1 | TP53 4231/4885LMNA 2316/4885THRB 1798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.