Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.65 |
| ▸ | KDR | P35968 | 12/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.57 |
| ▸ | FLT1 | P17948 | 2/20 | 0.57 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.57 |
| ▸ | FLT4 | P35916 | 2/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.57 |
| ▸ | FLT3 | P36888 | 2/20 | 0.57 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.57 |
| ▸ | STK10 | O94804 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | LYN | P07948 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
| ▸ | BCR | P11274 | 1/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.57 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13587160 | 0.88 | RAB9A (0.72) | METKDRPDGFRAFLT1EPHB2 | |
| SCHEMBL13587164 | 0.86 | MET (0.65) | METKDRPDGFRAFLT1FLT4 | |
| SCHEMBL13587149 | 0.86 | MET (0.65) | METKDRPDGFRAFLT1FLT4 | |
| SCHEMBL13587150 | 0.85 | NPC1 (0.72) | METKDRPDGFRALCKTEK | |
| SCHEMBL4378894 | 0.85 | MET (0.68) | METKDRPDGFRARAB9ANPC1 | |
| SCHEMBL4379209 | 0.85 | MET (0.70) | METKDRPDGFRARAB9ANPC1 | |
| SCHEMBL13587144 | 0.85 | MET (0.67) | METKDRPDGFRALCKTEK | |
| SCHEMBL13587165 | 0.84 | MET (0.67) | METKDRPDGFRALCKTEK | |
| SCHEMBL13587155 | 0.84 | MET (0.67) | METKDRPDGFRALCKTEK | |
| SCHEMBL4372566 | 0.84 | MET (0.67) | METKDRPDGFRAFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7626030-B2 | Compounds and methods of use | AMGEN INC. (US) | 2009-12-01 | — | — | US | disclosed |
| US-7626030-B2 | Compounds and methods of use | AMGEN INC. (US) | 2009-12-01 | — | — | US | disclosed |